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Experimental Schistosoma japonicum-induced pulmonary hypertension

BACKGROUND: Schistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species, Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-dependent S. mansoni pulmonary hypertension (PH)....

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Autores principales: Kassa, Biruk, Lee, Michael H., Kumar, Rahul, Mickael, Claudia, Sanders, Linda, Tuder, Rubin M., Mentink-Kane, Margaret, Graham, Brian B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037943/
https://www.ncbi.nlm.nih.gov/pubmed/35417453
http://dx.doi.org/10.1371/journal.pntd.0010343
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author Kassa, Biruk
Lee, Michael H.
Kumar, Rahul
Mickael, Claudia
Sanders, Linda
Tuder, Rubin M.
Mentink-Kane, Margaret
Graham, Brian B.
author_facet Kassa, Biruk
Lee, Michael H.
Kumar, Rahul
Mickael, Claudia
Sanders, Linda
Tuder, Rubin M.
Mentink-Kane, Margaret
Graham, Brian B.
author_sort Kassa, Biruk
collection PubMed
description BACKGROUND: Schistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species, Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-dependent S. mansoni pulmonary hypertension (PH). We sought to determine if another common species, S. japonicum, can also cause experimental PH. METHODS: Schistosome eggs were obtained from infected mice, and administered by intraperitoneal sensitization followed by intravenous challenge to experimental mice, which underwent right heart catheterization and tissue analysis. RESULTS: S. japonicum sensitized and challenged mice developed PH, which was milder than that following S. mansoni sensitization and challenge. The degree of pulmonary vascular remodeling and Type 2 inflammation in the lungs was similarly proportionate. Cross-sensitization revealed that antigens from either species are sufficient to sensitize for intravenous challenge with either egg, and the degree of PH severity depended on primarily the species used for intravenous challenge. Compared to a relatively uniform distribution of S. mansoni eggs, S. japonicum eggs were observed in clusters in the lungs. CONCLUSIONS: S. japonicum can induce experimental PH, which is milder than that resulting from comparable S. mansoni exposure. This difference may result from the distribution of eggs in the lungs, and is independent of which species is used for sensitization. This result is consistent with the clearer association between S. mansoni infection and the development of schistosomiasis-associated PAH in humans.
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spelling pubmed-90379432022-04-26 Experimental Schistosoma japonicum-induced pulmonary hypertension Kassa, Biruk Lee, Michael H. Kumar, Rahul Mickael, Claudia Sanders, Linda Tuder, Rubin M. Mentink-Kane, Margaret Graham, Brian B. PLoS Negl Trop Dis Research Article BACKGROUND: Schistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species, Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-dependent S. mansoni pulmonary hypertension (PH). We sought to determine if another common species, S. japonicum, can also cause experimental PH. METHODS: Schistosome eggs were obtained from infected mice, and administered by intraperitoneal sensitization followed by intravenous challenge to experimental mice, which underwent right heart catheterization and tissue analysis. RESULTS: S. japonicum sensitized and challenged mice developed PH, which was milder than that following S. mansoni sensitization and challenge. The degree of pulmonary vascular remodeling and Type 2 inflammation in the lungs was similarly proportionate. Cross-sensitization revealed that antigens from either species are sufficient to sensitize for intravenous challenge with either egg, and the degree of PH severity depended on primarily the species used for intravenous challenge. Compared to a relatively uniform distribution of S. mansoni eggs, S. japonicum eggs were observed in clusters in the lungs. CONCLUSIONS: S. japonicum can induce experimental PH, which is milder than that resulting from comparable S. mansoni exposure. This difference may result from the distribution of eggs in the lungs, and is independent of which species is used for sensitization. This result is consistent with the clearer association between S. mansoni infection and the development of schistosomiasis-associated PAH in humans. Public Library of Science 2022-04-13 /pmc/articles/PMC9037943/ /pubmed/35417453 http://dx.doi.org/10.1371/journal.pntd.0010343 Text en © 2022 Kassa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kassa, Biruk
Lee, Michael H.
Kumar, Rahul
Mickael, Claudia
Sanders, Linda
Tuder, Rubin M.
Mentink-Kane, Margaret
Graham, Brian B.
Experimental Schistosoma japonicum-induced pulmonary hypertension
title Experimental Schistosoma japonicum-induced pulmonary hypertension
title_full Experimental Schistosoma japonicum-induced pulmonary hypertension
title_fullStr Experimental Schistosoma japonicum-induced pulmonary hypertension
title_full_unstemmed Experimental Schistosoma japonicum-induced pulmonary hypertension
title_short Experimental Schistosoma japonicum-induced pulmonary hypertension
title_sort experimental schistosoma japonicum-induced pulmonary hypertension
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037943/
https://www.ncbi.nlm.nih.gov/pubmed/35417453
http://dx.doi.org/10.1371/journal.pntd.0010343
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