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Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging

Dietary restriction (DR) is the most successful nutritional intervention for extending lifespan and preserving health in numerous species. Reducing food intake triggers a protective response that shifts energy resources from growth to maintenance and resilience mechanisms. This so-called survival re...

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Autores principales: van den Boogaard, Winnie M.C., van den Heuvel-Eibrink, Marry M., Hoeijmakers, Jan H.J., Vermeij, Wilbert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037985/
https://www.ncbi.nlm.nih.gov/pubmed/35474917
http://dx.doi.org/10.1146/annurev-cancerbio-060820-090737
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author van den Boogaard, Winnie M.C.
van den Heuvel-Eibrink, Marry M.
Hoeijmakers, Jan H.J.
Vermeij, Wilbert P.
author_facet van den Boogaard, Winnie M.C.
van den Heuvel-Eibrink, Marry M.
Hoeijmakers, Jan H.J.
Vermeij, Wilbert P.
author_sort van den Boogaard, Winnie M.C.
collection PubMed
description Dietary restriction (DR) is the most successful nutritional intervention for extending lifespan and preserving health in numerous species. Reducing food intake triggers a protective response that shifts energy resources from growth to maintenance and resilience mechanisms. This so-called survival response has been shown to particularly increase life- and health span and decrease DNA damage in DNA repair–deficient mice exhibiting accelerated aging. Accumulation of DNA damage is the main cause of aging, but also of cancer. Moreover, radiotherapies and most chemotherapies are based on damaging DNA, consistent with their ability to induce toxicity and accelerate aging. Since fasting and DR decrease DNA damage and its effects, nutritional preconditioning holds promise for improving (cancer) therapy and preventing short- and long-term side effects of anticancer treatments. This review provides an overview of the link between aging and cancer, highlights important preclinical studies applying such nutritional preconditioning, and summarizes the first clinical trials implementing nutritional preconditioning in cancer treatment.
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spelling pubmed-90379852022-04-25 Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging van den Boogaard, Winnie M.C. van den Heuvel-Eibrink, Marry M. Hoeijmakers, Jan H.J. Vermeij, Wilbert P. Annu Rev Cancer Biol Article Dietary restriction (DR) is the most successful nutritional intervention for extending lifespan and preserving health in numerous species. Reducing food intake triggers a protective response that shifts energy resources from growth to maintenance and resilience mechanisms. This so-called survival response has been shown to particularly increase life- and health span and decrease DNA damage in DNA repair–deficient mice exhibiting accelerated aging. Accumulation of DNA damage is the main cause of aging, but also of cancer. Moreover, radiotherapies and most chemotherapies are based on damaging DNA, consistent with their ability to induce toxicity and accelerate aging. Since fasting and DR decrease DNA damage and its effects, nutritional preconditioning holds promise for improving (cancer) therapy and preventing short- and long-term side effects of anticancer treatments. This review provides an overview of the link between aging and cancer, highlights important preclinical studies applying such nutritional preconditioning, and summarizes the first clinical trials implementing nutritional preconditioning in cancer treatment. 2021-03 2020-12-02 /pmc/articles/PMC9037985/ /pubmed/35474917 http://dx.doi.org/10.1146/annurev-cancerbio-060820-090737 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 (https://creativecommons.org/licenses/by/4.0/) International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third-party material in this article for license information
spellingShingle Article
van den Boogaard, Winnie M.C.
van den Heuvel-Eibrink, Marry M.
Hoeijmakers, Jan H.J.
Vermeij, Wilbert P.
Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging
title Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging
title_full Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging
title_fullStr Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging
title_full_unstemmed Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging
title_short Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging
title_sort nutritional preconditioning in cancer treatment in relation to dna damage and aging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037985/
https://www.ncbi.nlm.nih.gov/pubmed/35474917
http://dx.doi.org/10.1146/annurev-cancerbio-060820-090737
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