Selective oxidation of alcohol-d(1) to aldehyde-d(1) using MnO(2)

The selective oxidation of alcohol-d(1) to prepare aldehyde-d(1) was newly developed by means of NaBD(4) reduction/activated MnO(2) oxidation. Various aldehyde-d(1) derivatives including aromatic and unsaturated aldehyde-d(1) can be prepared with a high deuterium incorporation ratio (up to 98% D). H...

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Detalles Bibliográficos
Autores principales: Okamura, Hironori, Yasuno, Yoko, Nakayama, Atsushi, Kumadaki, Katsushi, Kitsuwa, Kohei, Ozawa, Keita, Tamura, Yusaku, Yamamoto, Yuki, Shinada, Tetsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037989/
https://www.ncbi.nlm.nih.gov/pubmed/35478564
http://dx.doi.org/10.1039/d1ra05405h
Descripción
Sumario:The selective oxidation of alcohol-d(1) to prepare aldehyde-d(1) was newly developed by means of NaBD(4) reduction/activated MnO(2) oxidation. Various aldehyde-d(1) derivatives including aromatic and unsaturated aldehyde-d(1) can be prepared with a high deuterium incorporation ratio (up to 98% D). Halogens (chloride, bromide, and iodide), alkene, alkyne, ester, nitro, and cyano groups in the substrates are tolerated under the mild conditions.

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