Selective oxidation of alcohol-d(1) to aldehyde-d(1) using MnO(2)

The selective oxidation of alcohol-d(1) to prepare aldehyde-d(1) was newly developed by means of NaBD(4) reduction/activated MnO(2) oxidation. Various aldehyde-d(1) derivatives including aromatic and unsaturated aldehyde-d(1) can be prepared with a high deuterium incorporation ratio (up to 98% D). H...

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Autores principales: Okamura, Hironori, Yasuno, Yoko, Nakayama, Atsushi, Kumadaki, Katsushi, Kitsuwa, Kohei, Ozawa, Keita, Tamura, Yusaku, Yamamoto, Yuki, Shinada, Tetsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037989/
https://www.ncbi.nlm.nih.gov/pubmed/35478564
http://dx.doi.org/10.1039/d1ra05405h
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author Okamura, Hironori
Yasuno, Yoko
Nakayama, Atsushi
Kumadaki, Katsushi
Kitsuwa, Kohei
Ozawa, Keita
Tamura, Yusaku
Yamamoto, Yuki
Shinada, Tetsuro
author_facet Okamura, Hironori
Yasuno, Yoko
Nakayama, Atsushi
Kumadaki, Katsushi
Kitsuwa, Kohei
Ozawa, Keita
Tamura, Yusaku
Yamamoto, Yuki
Shinada, Tetsuro
author_sort Okamura, Hironori
collection PubMed
description The selective oxidation of alcohol-d(1) to prepare aldehyde-d(1) was newly developed by means of NaBD(4) reduction/activated MnO(2) oxidation. Various aldehyde-d(1) derivatives including aromatic and unsaturated aldehyde-d(1) can be prepared with a high deuterium incorporation ratio (up to 98% D). Halogens (chloride, bromide, and iodide), alkene, alkyne, ester, nitro, and cyano groups in the substrates are tolerated under the mild conditions.
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spelling pubmed-90379892022-04-26 Selective oxidation of alcohol-d(1) to aldehyde-d(1) using MnO(2) Okamura, Hironori Yasuno, Yoko Nakayama, Atsushi Kumadaki, Katsushi Kitsuwa, Kohei Ozawa, Keita Tamura, Yusaku Yamamoto, Yuki Shinada, Tetsuro RSC Adv Chemistry The selective oxidation of alcohol-d(1) to prepare aldehyde-d(1) was newly developed by means of NaBD(4) reduction/activated MnO(2) oxidation. Various aldehyde-d(1) derivatives including aromatic and unsaturated aldehyde-d(1) can be prepared with a high deuterium incorporation ratio (up to 98% D). Halogens (chloride, bromide, and iodide), alkene, alkyne, ester, nitro, and cyano groups in the substrates are tolerated under the mild conditions. The Royal Society of Chemistry 2021-08-24 /pmc/articles/PMC9037989/ /pubmed/35478564 http://dx.doi.org/10.1039/d1ra05405h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Okamura, Hironori
Yasuno, Yoko
Nakayama, Atsushi
Kumadaki, Katsushi
Kitsuwa, Kohei
Ozawa, Keita
Tamura, Yusaku
Yamamoto, Yuki
Shinada, Tetsuro
Selective oxidation of alcohol-d(1) to aldehyde-d(1) using MnO(2)
title Selective oxidation of alcohol-d(1) to aldehyde-d(1) using MnO(2)
title_full Selective oxidation of alcohol-d(1) to aldehyde-d(1) using MnO(2)
title_fullStr Selective oxidation of alcohol-d(1) to aldehyde-d(1) using MnO(2)
title_full_unstemmed Selective oxidation of alcohol-d(1) to aldehyde-d(1) using MnO(2)
title_short Selective oxidation of alcohol-d(1) to aldehyde-d(1) using MnO(2)
title_sort selective oxidation of alcohol-d(1) to aldehyde-d(1) using mno(2)
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037989/
https://www.ncbi.nlm.nih.gov/pubmed/35478564
http://dx.doi.org/10.1039/d1ra05405h
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