Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease

The papain-like protease (PLpro) of SARS-CoV-2 is essential for viral propagation and, additionally, dysregulation of the host innate immune system. Using a library of 40 potential metal-chelating compounds we performed an X-ray crystallographic screening against PLpro. As outcome we identified six...

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Detalles Bibliográficos
Autores principales: Ewert, Wiebke, Günther, Sebastian, Miglioli, Francesca, Falke, Sven, Reinke, Patrick Y. A., Niebling, Stephan, Günther, Christian, Han, Huijong, Srinivasan, Vasundara, Brognaro, Hévila, Lieske, Julia, Lorenzen, Kristina, Garcia-Alai, Maria M., Betzel, Christian, Carcelli, Mauro, Hinrichs, Winfried, Rogolino, Dominga, Meents, Alke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038201/
https://www.ncbi.nlm.nih.gov/pubmed/35480391
http://dx.doi.org/10.3389/fchem.2022.832431

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