Acute Tubulointerstitial Nephritis in Rosai-Dorfman Disease Mimicking IgG4-related Disease

Rosai-Dorfman-Destombes disease (RDD) is a non-Langerhans cell histiocytosis characterized by the accumulation of histiocytes inside the lymph nodes or extranodally. The association between RDD and IgG4-related disease (IgG4-RD) is discussed. We herein report a case of RDD manifesting as acute tubul...

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Autores principales: Kurahashi, Satoshi, Toda, Naohiro, Fujita, Masaaki, Tanigaki, Katsuya, Takeoka, Jun, Hirashima, Hisako, Muso, Eri, Io, Katsuhiro, Sakurai, Takaki, Komiya, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038462/
https://www.ncbi.nlm.nih.gov/pubmed/34544952
http://dx.doi.org/10.2169/internalmedicine.8046-21
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author Kurahashi, Satoshi
Toda, Naohiro
Fujita, Masaaki
Tanigaki, Katsuya
Takeoka, Jun
Hirashima, Hisako
Muso, Eri
Io, Katsuhiro
Sakurai, Takaki
Komiya, Toshiyuki
author_facet Kurahashi, Satoshi
Toda, Naohiro
Fujita, Masaaki
Tanigaki, Katsuya
Takeoka, Jun
Hirashima, Hisako
Muso, Eri
Io, Katsuhiro
Sakurai, Takaki
Komiya, Toshiyuki
author_sort Kurahashi, Satoshi
collection PubMed
description Rosai-Dorfman-Destombes disease (RDD) is a non-Langerhans cell histiocytosis characterized by the accumulation of histiocytes inside the lymph nodes or extranodally. The association between RDD and IgG4-related disease (IgG4-RD) is discussed. We herein report a case of RDD manifesting as acute tubulointerstitial nephritis mimicking IgG4-RD. The first renal biopsy showed severe tubulointerstitial nephritis with infiltration of S100-positive histiocytes and IgG4-positive plasma cells; storiform fibrosis and obliterative phlebitis were not confirmed. After prednisolone therapy, IgG4-positive cells and S100-positive histiocytes were decreased, but the IgG4/IgG ratio increased despite clinical improvement. These findings indicated extranodal RDD in the kidney presenting as tubulointerstitial nephritis.
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spelling pubmed-90384622022-05-06 Acute Tubulointerstitial Nephritis in Rosai-Dorfman Disease Mimicking IgG4-related Disease Kurahashi, Satoshi Toda, Naohiro Fujita, Masaaki Tanigaki, Katsuya Takeoka, Jun Hirashima, Hisako Muso, Eri Io, Katsuhiro Sakurai, Takaki Komiya, Toshiyuki Intern Med Case Report Rosai-Dorfman-Destombes disease (RDD) is a non-Langerhans cell histiocytosis characterized by the accumulation of histiocytes inside the lymph nodes or extranodally. The association between RDD and IgG4-related disease (IgG4-RD) is discussed. We herein report a case of RDD manifesting as acute tubulointerstitial nephritis mimicking IgG4-RD. The first renal biopsy showed severe tubulointerstitial nephritis with infiltration of S100-positive histiocytes and IgG4-positive plasma cells; storiform fibrosis and obliterative phlebitis were not confirmed. After prednisolone therapy, IgG4-positive cells and S100-positive histiocytes were decreased, but the IgG4/IgG ratio increased despite clinical improvement. These findings indicated extranodal RDD in the kidney presenting as tubulointerstitial nephritis. The Japanese Society of Internal Medicine 2021-09-18 2022-04-01 /pmc/articles/PMC9038462/ /pubmed/34544952 http://dx.doi.org/10.2169/internalmedicine.8046-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kurahashi, Satoshi
Toda, Naohiro
Fujita, Masaaki
Tanigaki, Katsuya
Takeoka, Jun
Hirashima, Hisako
Muso, Eri
Io, Katsuhiro
Sakurai, Takaki
Komiya, Toshiyuki
Acute Tubulointerstitial Nephritis in Rosai-Dorfman Disease Mimicking IgG4-related Disease
title Acute Tubulointerstitial Nephritis in Rosai-Dorfman Disease Mimicking IgG4-related Disease
title_full Acute Tubulointerstitial Nephritis in Rosai-Dorfman Disease Mimicking IgG4-related Disease
title_fullStr Acute Tubulointerstitial Nephritis in Rosai-Dorfman Disease Mimicking IgG4-related Disease
title_full_unstemmed Acute Tubulointerstitial Nephritis in Rosai-Dorfman Disease Mimicking IgG4-related Disease
title_short Acute Tubulointerstitial Nephritis in Rosai-Dorfman Disease Mimicking IgG4-related Disease
title_sort acute tubulointerstitial nephritis in rosai-dorfman disease mimicking igg4-related disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038462/
https://www.ncbi.nlm.nih.gov/pubmed/34544952
http://dx.doi.org/10.2169/internalmedicine.8046-21
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