IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination

A 28-year-old woman experienced gross hematuria after the administration of the second dose of an messenger ribonucleic acid (mRNA) vaccine (BNT162b2). She was diagnosed with Immunogloblin A nephropathy (IgAN) by a renal biopsy two weeks after vaccination, which revealed a mild increase in mesangial...

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Autores principales: Nihei, Yoshihito, Kishi, Monami, Suzuki, Hitoshi, Koizumi, Ayako, Yoshida, Maiko, Hamaguchi, Sho, Iwasaki, Masako, Fukuda, Hiromitsu, Takahara, Hisatsugu, Kihara, Masao, Tomita, Shigeki, Suzuki, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038465/
https://www.ncbi.nlm.nih.gov/pubmed/35110484
http://dx.doi.org/10.2169/internalmedicine.8787-21
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author Nihei, Yoshihito
Kishi, Monami
Suzuki, Hitoshi
Koizumi, Ayako
Yoshida, Maiko
Hamaguchi, Sho
Iwasaki, Masako
Fukuda, Hiromitsu
Takahara, Hisatsugu
Kihara, Masao
Tomita, Shigeki
Suzuki, Yusuke
author_facet Nihei, Yoshihito
Kishi, Monami
Suzuki, Hitoshi
Koizumi, Ayako
Yoshida, Maiko
Hamaguchi, Sho
Iwasaki, Masako
Fukuda, Hiromitsu
Takahara, Hisatsugu
Kihara, Masao
Tomita, Shigeki
Suzuki, Yusuke
author_sort Nihei, Yoshihito
collection PubMed
description A 28-year-old woman experienced gross hematuria after the administration of the second dose of an messenger ribonucleic acid (mRNA) vaccine (BNT162b2). She was diagnosed with Immunogloblin A nephropathy (IgAN) by a renal biopsy two weeks after vaccination, which revealed a mild increase in mesangial cells and a matrix with co-depositions of galactose-deficient IgA1 and C3 in the mesangial region. The gross hematuria and proteinuria gradually improved without any medication, suggesting that immune activation by the mRNA vaccine may not elicit continuous disease progression of IgAN. Thus, further studies investigating the relationship between mRNA vaccines against COVID-19 and the progression of IgAN should be conducted.
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spelling pubmed-90384652022-05-06 IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination Nihei, Yoshihito Kishi, Monami Suzuki, Hitoshi Koizumi, Ayako Yoshida, Maiko Hamaguchi, Sho Iwasaki, Masako Fukuda, Hiromitsu Takahara, Hisatsugu Kihara, Masao Tomita, Shigeki Suzuki, Yusuke Intern Med Case Report A 28-year-old woman experienced gross hematuria after the administration of the second dose of an messenger ribonucleic acid (mRNA) vaccine (BNT162b2). She was diagnosed with Immunogloblin A nephropathy (IgAN) by a renal biopsy two weeks after vaccination, which revealed a mild increase in mesangial cells and a matrix with co-depositions of galactose-deficient IgA1 and C3 in the mesangial region. The gross hematuria and proteinuria gradually improved without any medication, suggesting that immune activation by the mRNA vaccine may not elicit continuous disease progression of IgAN. Thus, further studies investigating the relationship between mRNA vaccines against COVID-19 and the progression of IgAN should be conducted. The Japanese Society of Internal Medicine 2022-02-01 2022-04-01 /pmc/articles/PMC9038465/ /pubmed/35110484 http://dx.doi.org/10.2169/internalmedicine.8787-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nihei, Yoshihito
Kishi, Monami
Suzuki, Hitoshi
Koizumi, Ayako
Yoshida, Maiko
Hamaguchi, Sho
Iwasaki, Masako
Fukuda, Hiromitsu
Takahara, Hisatsugu
Kihara, Masao
Tomita, Shigeki
Suzuki, Yusuke
IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination
title IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination
title_full IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination
title_fullStr IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination
title_full_unstemmed IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination
title_short IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination
title_sort iga nephropathy with gross hematuria following covid-19 mrna vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038465/
https://www.ncbi.nlm.nih.gov/pubmed/35110484
http://dx.doi.org/10.2169/internalmedicine.8787-21
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