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Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury

Infections with neuraminidase-producing bacteria can lead to acute kidney injury (AKI). We herein report a 74-year-old woman who developed AKI in the course of Capnocytophaga infection, a neuraminidase-producing bacterium. A renal biopsy showed tubulointerstitial injury accompanied by specific bindi...

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Autores principales: Uchida, Takahiro, Oda, Takashi, Inoue, Dan, Komatsu, Shuhei, Kojima, Tadasu, Tomiyasu, Tomohiro, Yoshikawa, Noriko, Yamada, Muneharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038469/
https://www.ncbi.nlm.nih.gov/pubmed/34471025
http://dx.doi.org/10.2169/internalmedicine.7809-21
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author Uchida, Takahiro
Oda, Takashi
Inoue, Dan
Komatsu, Shuhei
Kojima, Tadasu
Tomiyasu, Tomohiro
Yoshikawa, Noriko
Yamada, Muneharu
author_facet Uchida, Takahiro
Oda, Takashi
Inoue, Dan
Komatsu, Shuhei
Kojima, Tadasu
Tomiyasu, Tomohiro
Yoshikawa, Noriko
Yamada, Muneharu
author_sort Uchida, Takahiro
collection PubMed
description Infections with neuraminidase-producing bacteria can lead to acute kidney injury (AKI). We herein report a 74-year-old woman who developed AKI in the course of Capnocytophaga infection, a neuraminidase-producing bacterium. A renal biopsy showed tubulointerstitial injury accompanied by specific binding of fluorescence-conjugated peanut lectin to the tubular epithelial cells, suggesting exposure of Thomsen-Friedenreich antigen (T-antigen) on the tubules. Although AKI is often observed in patients infected with Capnocytophaga, little is known about its etiology and associated pathology. This case suggests that tubulointerstitial injury caused by neuraminidase production and resultant T-antigen exposure is a mechanism of Capnocytophaga infection-induced AKI.
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spelling pubmed-90384692022-05-06 Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury Uchida, Takahiro Oda, Takashi Inoue, Dan Komatsu, Shuhei Kojima, Tadasu Tomiyasu, Tomohiro Yoshikawa, Noriko Yamada, Muneharu Intern Med Case Report Infections with neuraminidase-producing bacteria can lead to acute kidney injury (AKI). We herein report a 74-year-old woman who developed AKI in the course of Capnocytophaga infection, a neuraminidase-producing bacterium. A renal biopsy showed tubulointerstitial injury accompanied by specific binding of fluorescence-conjugated peanut lectin to the tubular epithelial cells, suggesting exposure of Thomsen-Friedenreich antigen (T-antigen) on the tubules. Although AKI is often observed in patients infected with Capnocytophaga, little is known about its etiology and associated pathology. This case suggests that tubulointerstitial injury caused by neuraminidase production and resultant T-antigen exposure is a mechanism of Capnocytophaga infection-induced AKI. The Japanese Society of Internal Medicine 2021-08-31 2022-04-01 /pmc/articles/PMC9038469/ /pubmed/34471025 http://dx.doi.org/10.2169/internalmedicine.7809-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Uchida, Takahiro
Oda, Takashi
Inoue, Dan
Komatsu, Shuhei
Kojima, Tadasu
Tomiyasu, Tomohiro
Yoshikawa, Noriko
Yamada, Muneharu
Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury
title Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury
title_full Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury
title_fullStr Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury
title_full_unstemmed Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury
title_short Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury
title_sort exposure of thomsen-friedenreich antigen on the renal tubules of a patient with capnocytophaga infection-induced acute kidney injury
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038469/
https://www.ncbi.nlm.nih.gov/pubmed/34471025
http://dx.doi.org/10.2169/internalmedicine.7809-21
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