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The Albumin-bilirubin Score Detects Changes in the Liver Function during Treatment for Budd-Chiari Syndrome: A Retrospective Observational Study

OBJECTIVE: Mapping the long-term prognosis of Budd-Chiari syndrome (BCS) is difficult, as the prognosis is associated with changes in the liver function. The present study evaluated the time course changes in the liver function in a treatment group with percutaneous old balloon angioplasty (POBA) an...

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Autores principales: Kageyama, Ken, Yamamoto, Akira, Jogo, Atsushi, Sohgawa, Etsuji, Hagihara, Atsushi, Fujii, Hideki, Uchida-Kobayashi, Sawako, Kawada, Norifumi, Miki, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038474/
https://www.ncbi.nlm.nih.gov/pubmed/34544949
http://dx.doi.org/10.2169/internalmedicine.8020-21
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author Kageyama, Ken
Yamamoto, Akira
Jogo, Atsushi
Sohgawa, Etsuji
Hagihara, Atsushi
Fujii, Hideki
Uchida-Kobayashi, Sawako
Kawada, Norifumi
Miki, Yukio
author_facet Kageyama, Ken
Yamamoto, Akira
Jogo, Atsushi
Sohgawa, Etsuji
Hagihara, Atsushi
Fujii, Hideki
Uchida-Kobayashi, Sawako
Kawada, Norifumi
Miki, Yukio
author_sort Kageyama, Ken
collection PubMed
description OBJECTIVE: Mapping the long-term prognosis of Budd-Chiari syndrome (BCS) is difficult, as the prognosis is associated with changes in the liver function. The present study evaluated the time course changes in the liver function in a treatment group with percutaneous old balloon angioplasty (POBA) and a non-treatment group using the albumin-bilirubin score (ALBI) and Child-Pugh score during long-term follow-up. METHODS: In this retrospective study, 13 consecutive patients diagnosed with BCS at our hospital between 2007 and 2020 were categorized into a treatment group (n=8), which received POBA, and a non-treatment group (n=5). Differences in the liver function in the ALBI and Child-Pugh scores between the initial visit and one- and three-year follow-up were calculated and statistically evaluated. We investigated the changes in the liver function during the long-term follow-up, including events such as re-stenosis and re-treatment. RESULTS: While the Child-Pugh scores in the treatment group did not differ significantly between the initial visit and 1- or 3-year follow-up, the ALBI scores in this group improved significantly between the initial visit and the 1- or 3-year follow-up visit (p=0.0078 and 0.0156, respectively). The liver function according to the ALBI score in the treatment group showed gradual improvement from the initial value but gradual worsening in the non-treatment group. The ALBI scores also revealed that the liver function varies according to re-stenosis and re-POBA in BCS patients. CONCLUSION: Unlike the Child-Pugh score, the ALBI score was able to capture changes in the liver function of BCS patients during the long-term course of BCS.
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spelling pubmed-90384742022-05-06 The Albumin-bilirubin Score Detects Changes in the Liver Function during Treatment for Budd-Chiari Syndrome: A Retrospective Observational Study Kageyama, Ken Yamamoto, Akira Jogo, Atsushi Sohgawa, Etsuji Hagihara, Atsushi Fujii, Hideki Uchida-Kobayashi, Sawako Kawada, Norifumi Miki, Yukio Intern Med Original Article OBJECTIVE: Mapping the long-term prognosis of Budd-Chiari syndrome (BCS) is difficult, as the prognosis is associated with changes in the liver function. The present study evaluated the time course changes in the liver function in a treatment group with percutaneous old balloon angioplasty (POBA) and a non-treatment group using the albumin-bilirubin score (ALBI) and Child-Pugh score during long-term follow-up. METHODS: In this retrospective study, 13 consecutive patients diagnosed with BCS at our hospital between 2007 and 2020 were categorized into a treatment group (n=8), which received POBA, and a non-treatment group (n=5). Differences in the liver function in the ALBI and Child-Pugh scores between the initial visit and one- and three-year follow-up were calculated and statistically evaluated. We investigated the changes in the liver function during the long-term follow-up, including events such as re-stenosis and re-treatment. RESULTS: While the Child-Pugh scores in the treatment group did not differ significantly between the initial visit and 1- or 3-year follow-up, the ALBI scores in this group improved significantly between the initial visit and the 1- or 3-year follow-up visit (p=0.0078 and 0.0156, respectively). The liver function according to the ALBI score in the treatment group showed gradual improvement from the initial value but gradual worsening in the non-treatment group. The ALBI scores also revealed that the liver function varies according to re-stenosis and re-POBA in BCS patients. CONCLUSION: Unlike the Child-Pugh score, the ALBI score was able to capture changes in the liver function of BCS patients during the long-term course of BCS. The Japanese Society of Internal Medicine 2021-09-18 2022-04-01 /pmc/articles/PMC9038474/ /pubmed/34544949 http://dx.doi.org/10.2169/internalmedicine.8020-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Kageyama, Ken
Yamamoto, Akira
Jogo, Atsushi
Sohgawa, Etsuji
Hagihara, Atsushi
Fujii, Hideki
Uchida-Kobayashi, Sawako
Kawada, Norifumi
Miki, Yukio
The Albumin-bilirubin Score Detects Changes in the Liver Function during Treatment for Budd-Chiari Syndrome: A Retrospective Observational Study
title The Albumin-bilirubin Score Detects Changes in the Liver Function during Treatment for Budd-Chiari Syndrome: A Retrospective Observational Study
title_full The Albumin-bilirubin Score Detects Changes in the Liver Function during Treatment for Budd-Chiari Syndrome: A Retrospective Observational Study
title_fullStr The Albumin-bilirubin Score Detects Changes in the Liver Function during Treatment for Budd-Chiari Syndrome: A Retrospective Observational Study
title_full_unstemmed The Albumin-bilirubin Score Detects Changes in the Liver Function during Treatment for Budd-Chiari Syndrome: A Retrospective Observational Study
title_short The Albumin-bilirubin Score Detects Changes in the Liver Function during Treatment for Budd-Chiari Syndrome: A Retrospective Observational Study
title_sort albumin-bilirubin score detects changes in the liver function during treatment for budd-chiari syndrome: a retrospective observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038474/
https://www.ncbi.nlm.nih.gov/pubmed/34544949
http://dx.doi.org/10.2169/internalmedicine.8020-21
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