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Dermatomyositis Which Was Double Positive for Anti-MDA5 and Anti-ARS Antibodies That Was Successfully Treated by Intensive Immunosuppressive Therapy
Myositis-specific autoantibody is associated with the clinical phenotype and prognosis of dermatomyositis. Anti-melanoma differentiation-associated gene 5 (MDA5) and anti-aminoacyl-tRNA synthetase (ARS) antibodies are generally mutually exclusive. We herein present an extremely rare case of dermatom...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038476/ https://www.ncbi.nlm.nih.gov/pubmed/35370250 http://dx.doi.org/10.2169/internalmedicine.8579-21 |
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author | Hama, Satoshi Higashida-Konishi, Misako Akiyama, Mitsuhiro Shimada, Tatsuya Takei, Hiroshi Izumi, Keisuke Oshima, Hisaji Okano, Yutaka |
author_facet | Hama, Satoshi Higashida-Konishi, Misako Akiyama, Mitsuhiro Shimada, Tatsuya Takei, Hiroshi Izumi, Keisuke Oshima, Hisaji Okano, Yutaka |
author_sort | Hama, Satoshi |
collection | PubMed |
description | Myositis-specific autoantibody is associated with the clinical phenotype and prognosis of dermatomyositis. Anti-melanoma differentiation-associated gene 5 (MDA5) and anti-aminoacyl-tRNA synthetase (ARS) antibodies are generally mutually exclusive. We herein present an extremely rare case of dermatomyositis which showed double positivity for anti-MDA5 and anti-ARS antibodies. There have been very few reported cases of double positive anti-MDA5, anti-ARS antibodies. In such cases, the clinical characteristics of each autoantibody can coexist. Thus, we should pay attention to the rapidly progressing features of anti-MDA5 as well as the chronic relapsing features of anti-ARS for the better management of this rare condition. |
format | Online Article Text |
id | pubmed-9038476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-90384762022-05-06 Dermatomyositis Which Was Double Positive for Anti-MDA5 and Anti-ARS Antibodies That Was Successfully Treated by Intensive Immunosuppressive Therapy Hama, Satoshi Higashida-Konishi, Misako Akiyama, Mitsuhiro Shimada, Tatsuya Takei, Hiroshi Izumi, Keisuke Oshima, Hisaji Okano, Yutaka Intern Med Case Report Myositis-specific autoantibody is associated with the clinical phenotype and prognosis of dermatomyositis. Anti-melanoma differentiation-associated gene 5 (MDA5) and anti-aminoacyl-tRNA synthetase (ARS) antibodies are generally mutually exclusive. We herein present an extremely rare case of dermatomyositis which showed double positivity for anti-MDA5 and anti-ARS antibodies. There have been very few reported cases of double positive anti-MDA5, anti-ARS antibodies. In such cases, the clinical characteristics of each autoantibody can coexist. Thus, we should pay attention to the rapidly progressing features of anti-MDA5 as well as the chronic relapsing features of anti-ARS for the better management of this rare condition. The Japanese Society of Internal Medicine 2022-04-01 2022-04-01 /pmc/articles/PMC9038476/ /pubmed/35370250 http://dx.doi.org/10.2169/internalmedicine.8579-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Hama, Satoshi Higashida-Konishi, Misako Akiyama, Mitsuhiro Shimada, Tatsuya Takei, Hiroshi Izumi, Keisuke Oshima, Hisaji Okano, Yutaka Dermatomyositis Which Was Double Positive for Anti-MDA5 and Anti-ARS Antibodies That Was Successfully Treated by Intensive Immunosuppressive Therapy |
title | Dermatomyositis Which Was Double Positive for Anti-MDA5 and Anti-ARS Antibodies That Was Successfully Treated by Intensive Immunosuppressive Therapy |
title_full | Dermatomyositis Which Was Double Positive for Anti-MDA5 and Anti-ARS Antibodies That Was Successfully Treated by Intensive Immunosuppressive Therapy |
title_fullStr | Dermatomyositis Which Was Double Positive for Anti-MDA5 and Anti-ARS Antibodies That Was Successfully Treated by Intensive Immunosuppressive Therapy |
title_full_unstemmed | Dermatomyositis Which Was Double Positive for Anti-MDA5 and Anti-ARS Antibodies That Was Successfully Treated by Intensive Immunosuppressive Therapy |
title_short | Dermatomyositis Which Was Double Positive for Anti-MDA5 and Anti-ARS Antibodies That Was Successfully Treated by Intensive Immunosuppressive Therapy |
title_sort | dermatomyositis which was double positive for anti-mda5 and anti-ars antibodies that was successfully treated by intensive immunosuppressive therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038476/ https://www.ncbi.nlm.nih.gov/pubmed/35370250 http://dx.doi.org/10.2169/internalmedicine.8579-21 |
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