A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4(+) T cells and is defective in Crohn´s disease patients

Immunosuppressive Interleukin (IL)−10 production by pro-inflammatory CD4(+) T cells is a central self-regulatory function to limit aberrant inflammation. Still, the molecular mediators controlling IL-10 expression in human CD4(+) T cells are largely undefined. Here, we identify a Notch/STAT3 signali...

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Detalles Bibliográficos
Autores principales: Ahlers, Jonas, Mantei, Andrej, Lozza, Laura, Stäber, Manuela, Heinrich, Frederik, Bacher, Petra, Hohnstein, Thordis, Menzel, Lutz, Yüz, Simge G., Alvarez-Simon, Daniel, Bickenbach, Anne Rieke, Weidinger, Carl, Mockel-Tenbrinck, Nadine, Kühl, Anja A., Siegmund, Britta, Maul, Jochen, Neumann, Christian, Scheffold, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038525/
https://www.ncbi.nlm.nih.gov/pubmed/35169232
http://dx.doi.org/10.1038/s41385-022-00487-x

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