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Vitamin A Status Is More Commonly Associated With Symptoms and Neurodevelopment in Boys With Autism Spectrum Disorders—A Multicenter Study in China
BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder, and show a striking male bias in prevalence. Vitamin A (VA) is essential for brain development, and abnormalities in its metabolite retinoic acid are associated with the pathophysiology of ASD. This national multicenter stu...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038535/ https://www.ncbi.nlm.nih.gov/pubmed/35495950 http://dx.doi.org/10.3389/fnut.2022.851980 |
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author | Yang, Ting Chen, Li Dai, Ying Jia, Feiyong Hao, Yan Li, Ling Zhang, Jie Wu, Lijie Ke, Xiaoyan Yi, Mingji Hong, Qi Chen, Jinjin Fang, Shuanfeng Wang, Yichao Wang, Qi Jin, Chunhua Chen, Jie Li, Tingyu |
author_facet | Yang, Ting Chen, Li Dai, Ying Jia, Feiyong Hao, Yan Li, Ling Zhang, Jie Wu, Lijie Ke, Xiaoyan Yi, Mingji Hong, Qi Chen, Jinjin Fang, Shuanfeng Wang, Yichao Wang, Qi Jin, Chunhua Chen, Jie Li, Tingyu |
author_sort | Yang, Ting |
collection | PubMed |
description | BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder, and show a striking male bias in prevalence. Vitamin A (VA) is essential for brain development, and abnormalities in its metabolite retinoic acid are associated with the pathophysiology of ASD. This national multicenter study was conducted to investigate the relationship between serum VA level and core symptoms in ASD children and whether there are still sex differences. METHOD: A total of 1,300 children with ASD and 1,252 typically-developing (TD) controls aged 2–7 years old from 13 cities in China were enrolled in this study. The symptoms of children with ASD were evaluated by the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Childhood autism rating scale (CARS). The neurodevelopmental level of the children was evaluated with the revised Children Neuropsychological and Behavior Scale (CNBS-R2016). The serum level of VA was measured by high-performance liquid chromatography (HPLC). RESULTS: The serum VA level in children with ASD was significantly lower than that in TD children, especially in boys with ASD. Furthermore, VA levels in male children with ASD were lower than those in female children with ASD. In addition, we found that serum VA level was negatively correlated the SRS, CARS and communication warming behavior of CBNS-R2016 scores in boys with ASD. In terms of developmental quotients, serum VA level was positively associated with the general quotient, language quotient, gross motor quotient and personal-social quotient of boys with ASD, but no difference was found in girls with ASD. CONCLUSIONS: ASD children, especially boys, have lower serum VA levels than TD children. Moreover, serum VA status is more commonly associated with clinical symptoms and neurodevelopment in boys with ASD. |
format | Online Article Text |
id | pubmed-9038535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90385352022-04-27 Vitamin A Status Is More Commonly Associated With Symptoms and Neurodevelopment in Boys With Autism Spectrum Disorders—A Multicenter Study in China Yang, Ting Chen, Li Dai, Ying Jia, Feiyong Hao, Yan Li, Ling Zhang, Jie Wu, Lijie Ke, Xiaoyan Yi, Mingji Hong, Qi Chen, Jinjin Fang, Shuanfeng Wang, Yichao Wang, Qi Jin, Chunhua Chen, Jie Li, Tingyu Front Nutr Nutrition BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder, and show a striking male bias in prevalence. Vitamin A (VA) is essential for brain development, and abnormalities in its metabolite retinoic acid are associated with the pathophysiology of ASD. This national multicenter study was conducted to investigate the relationship between serum VA level and core symptoms in ASD children and whether there are still sex differences. METHOD: A total of 1,300 children with ASD and 1,252 typically-developing (TD) controls aged 2–7 years old from 13 cities in China were enrolled in this study. The symptoms of children with ASD were evaluated by the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Childhood autism rating scale (CARS). The neurodevelopmental level of the children was evaluated with the revised Children Neuropsychological and Behavior Scale (CNBS-R2016). The serum level of VA was measured by high-performance liquid chromatography (HPLC). RESULTS: The serum VA level in children with ASD was significantly lower than that in TD children, especially in boys with ASD. Furthermore, VA levels in male children with ASD were lower than those in female children with ASD. In addition, we found that serum VA level was negatively correlated the SRS, CARS and communication warming behavior of CBNS-R2016 scores in boys with ASD. In terms of developmental quotients, serum VA level was positively associated with the general quotient, language quotient, gross motor quotient and personal-social quotient of boys with ASD, but no difference was found in girls with ASD. CONCLUSIONS: ASD children, especially boys, have lower serum VA levels than TD children. Moreover, serum VA status is more commonly associated with clinical symptoms and neurodevelopment in boys with ASD. Frontiers Media S.A. 2022-04-05 /pmc/articles/PMC9038535/ /pubmed/35495950 http://dx.doi.org/10.3389/fnut.2022.851980 Text en Copyright © 2022 Yang, Chen, Dai, Jia, Hao, Li, Zhang, Wu, Ke, Yi, Hong, Chen, Fang, Wang, Wang, Jin, Chen and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Yang, Ting Chen, Li Dai, Ying Jia, Feiyong Hao, Yan Li, Ling Zhang, Jie Wu, Lijie Ke, Xiaoyan Yi, Mingji Hong, Qi Chen, Jinjin Fang, Shuanfeng Wang, Yichao Wang, Qi Jin, Chunhua Chen, Jie Li, Tingyu Vitamin A Status Is More Commonly Associated With Symptoms and Neurodevelopment in Boys With Autism Spectrum Disorders—A Multicenter Study in China |
title | Vitamin A Status Is More Commonly Associated With Symptoms and Neurodevelopment in Boys With Autism Spectrum Disorders—A Multicenter Study in China |
title_full | Vitamin A Status Is More Commonly Associated With Symptoms and Neurodevelopment in Boys With Autism Spectrum Disorders—A Multicenter Study in China |
title_fullStr | Vitamin A Status Is More Commonly Associated With Symptoms and Neurodevelopment in Boys With Autism Spectrum Disorders—A Multicenter Study in China |
title_full_unstemmed | Vitamin A Status Is More Commonly Associated With Symptoms and Neurodevelopment in Boys With Autism Spectrum Disorders—A Multicenter Study in China |
title_short | Vitamin A Status Is More Commonly Associated With Symptoms and Neurodevelopment in Boys With Autism Spectrum Disorders—A Multicenter Study in China |
title_sort | vitamin a status is more commonly associated with symptoms and neurodevelopment in boys with autism spectrum disorders—a multicenter study in china |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038535/ https://www.ncbi.nlm.nih.gov/pubmed/35495950 http://dx.doi.org/10.3389/fnut.2022.851980 |
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