Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents

Solid tumours are often poorly oxygenated, which confers resistance to standard treatment modalities. Targeting hypoxic tumours requires compounds, such as nitroimidazoles (NIs), equipped with the ability to reach and become activated within diffusion limited tumour niches. NIs become selectively en...

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Detalles Bibliográficos
Autores principales: Rashed, Faisal Bin, Diaz-Dussan, Diana, Mashayekhi, Fatemeh, Macdonald, Dawn, Nation, Patrick Nicholas, Yang, Xiao-Hong, Sokhi, Sargun, Stoica, Alexandru Cezar, El-Saidi, Hassan, Ricardo, Carolynne, Narain, Ravin, Ismail, Ismail Hassan, Wiebe, Leonard Irving, Kumar, Piyush, Weinfeld, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038562/
https://www.ncbi.nlm.nih.gov/pubmed/35430547
http://dx.doi.org/10.1016/j.redox.2022.102300

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