Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii

We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress condi...

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Autores principales: Whiteway, Clémence, Valcek, Adam, Philippe, Chantal, Strazisar, Mojca, De Pooter, Tim, Mateus, Ivan, Breine, Anke, Van der Henst, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038732/
https://www.ncbi.nlm.nih.gov/pubmed/34949784
http://dx.doi.org/10.1038/s41396-021-01179-3
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author Whiteway, Clémence
Valcek, Adam
Philippe, Chantal
Strazisar, Mojca
De Pooter, Tim
Mateus, Ivan
Breine, Anke
Van der Henst, Charles
author_facet Whiteway, Clémence
Valcek, Adam
Philippe, Chantal
Strazisar, Mojca
De Pooter, Tim
Mateus, Ivan
Breine, Anke
Van der Henst, Charles
author_sort Whiteway, Clémence
collection PubMed
description We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance.
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spelling pubmed-90387322022-04-28 Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii Whiteway, Clémence Valcek, Adam Philippe, Chantal Strazisar, Mojca De Pooter, Tim Mateus, Ivan Breine, Anke Van der Henst, Charles ISME J Brief Communication We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance. Nature Publishing Group UK 2021-12-23 2022-05 /pmc/articles/PMC9038732/ /pubmed/34949784 http://dx.doi.org/10.1038/s41396-021-01179-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Whiteway, Clémence
Valcek, Adam
Philippe, Chantal
Strazisar, Mojca
De Pooter, Tim
Mateus, Ivan
Breine, Anke
Van der Henst, Charles
Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii
title Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii
title_full Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii
title_fullStr Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii
title_full_unstemmed Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii
title_short Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii
title_sort scarless excision of an insertion sequence restores capsule production and virulence in acinetobacter baumannii
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038732/
https://www.ncbi.nlm.nih.gov/pubmed/34949784
http://dx.doi.org/10.1038/s41396-021-01179-3
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