Molecular mechanisms of bifunctional vitamin D receptor agonist-histone deacetylase inhibitor hybrid molecules in triple-negative breast cancer

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), and its analogues signal through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor, and have been extensively investigated as anticancer agents. 1,25D and its analogs have potential in combination therapies be...

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Detalles Bibliográficos
Autores principales: Barbier, Camille, Mansour, Ali, Ismailova, Aiten, Sarmadi, Fatemeh, Scarlata, David A., Bouttier, Manuella, Zeitouni, Camille, Wang, Catherine, Gleason, James L., White, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038752/
https://www.ncbi.nlm.nih.gov/pubmed/35468986
http://dx.doi.org/10.1038/s41598-022-10740-9

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