Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes

Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson’s disease (PD). Intere...

Descripción completa

Detalles Bibliográficos
Autores principales: Chegão, Ana, Guarda, Mariana, Alexandre, Bruno M., Shvachiy, Liana, Temido-Ferreira, Mariana, Marques-Morgado, Inês, Fernandes Gomes, Bárbara, Matthiesen, Rune, Lopes, Luísa V., Florindo, Pedro R., Gomes, Ricardo A., Gomes-Alves, Patrícia, Coelho, Joana E., Outeiro, Tiago Fleming, Vicente Miranda, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038780/
https://www.ncbi.nlm.nih.gov/pubmed/35468899
http://dx.doi.org/10.1038/s41531-022-00314-x

Ejemplares similares

Ejemplares similares