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Role of liver stiffness measurements in patients who develop hepatocellular carcinoma after clearance of the hepatitis C virus
PURPOSE: To measure changes in liver stiffness over time due to direct-acting antiviral (DAA) therapy in hepatitis C patients using shear wave elastography (SWE). METHODS: Patients with hepatitis C treated with DAA therapy in a university medical center between July 2015 and April 2020 were evaluate...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038899/ https://www.ncbi.nlm.nih.gov/pubmed/35129720 http://dx.doi.org/10.1007/s10396-021-01188-x |
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author | Gyotoku, Yoshinori Shirahashi, Ryosaku Suda, Toshikuni Tamano, Masaya |
author_facet | Gyotoku, Yoshinori Shirahashi, Ryosaku Suda, Toshikuni Tamano, Masaya |
author_sort | Gyotoku, Yoshinori |
collection | PubMed |
description | PURPOSE: To measure changes in liver stiffness over time due to direct-acting antiviral (DAA) therapy in hepatitis C patients using shear wave elastography (SWE). METHODS: Patients with hepatitis C treated with DAA therapy in a university medical center between July 2015 and April 2020 were evaluated. Shear wave velocity (Vs) of the liver was measured using SWE. Alanine aminotransferase (ALT), platelet count, and α-fetoprotein (AFP) were measured at the same time, and the FIB-4 index was estimated. Absence of hepatocellular carcinoma was confirmed at baseline and end of therapy. Imaging was then performed every 6 months. Patient characteristics were compared between patients who did and did not develop carcinoma. RESULTS: The mean age of the 229 patients (93 men) was 65.6 years. Eight patients developed carcinoma during follow-up (mean 32.6 ± 19.5 months). Significant differences were found between the groups in terms of AFP, platelet count, and Fib-4 index at baseline; the pre-treatment data had the best relationship with hepatocarcinogenesis. Mean Vs decreased significantly during DAA therapy, and then decreased further. Liver stiffness 6 months after treatment ended had the best relationship with hepatocarcinogenesis. CONCLUSION: In patients with a sustained virological response, risk of developing cancer can be predicted by measuring Vs approximately 6 months after treatment. |
format | Online Article Text |
id | pubmed-9038899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-90388992022-05-07 Role of liver stiffness measurements in patients who develop hepatocellular carcinoma after clearance of the hepatitis C virus Gyotoku, Yoshinori Shirahashi, Ryosaku Suda, Toshikuni Tamano, Masaya J Med Ultrason (2001) Original Article–Gastroenterology PURPOSE: To measure changes in liver stiffness over time due to direct-acting antiviral (DAA) therapy in hepatitis C patients using shear wave elastography (SWE). METHODS: Patients with hepatitis C treated with DAA therapy in a university medical center between July 2015 and April 2020 were evaluated. Shear wave velocity (Vs) of the liver was measured using SWE. Alanine aminotransferase (ALT), platelet count, and α-fetoprotein (AFP) were measured at the same time, and the FIB-4 index was estimated. Absence of hepatocellular carcinoma was confirmed at baseline and end of therapy. Imaging was then performed every 6 months. Patient characteristics were compared between patients who did and did not develop carcinoma. RESULTS: The mean age of the 229 patients (93 men) was 65.6 years. Eight patients developed carcinoma during follow-up (mean 32.6 ± 19.5 months). Significant differences were found between the groups in terms of AFP, platelet count, and Fib-4 index at baseline; the pre-treatment data had the best relationship with hepatocarcinogenesis. Mean Vs decreased significantly during DAA therapy, and then decreased further. Liver stiffness 6 months after treatment ended had the best relationship with hepatocarcinogenesis. CONCLUSION: In patients with a sustained virological response, risk of developing cancer can be predicted by measuring Vs approximately 6 months after treatment. Springer Nature Singapore 2022-02-07 2022 /pmc/articles/PMC9038899/ /pubmed/35129720 http://dx.doi.org/10.1007/s10396-021-01188-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article–Gastroenterology Gyotoku, Yoshinori Shirahashi, Ryosaku Suda, Toshikuni Tamano, Masaya Role of liver stiffness measurements in patients who develop hepatocellular carcinoma after clearance of the hepatitis C virus |
title | Role of liver stiffness measurements in patients who develop hepatocellular carcinoma after clearance of the hepatitis C virus |
title_full | Role of liver stiffness measurements in patients who develop hepatocellular carcinoma after clearance of the hepatitis C virus |
title_fullStr | Role of liver stiffness measurements in patients who develop hepatocellular carcinoma after clearance of the hepatitis C virus |
title_full_unstemmed | Role of liver stiffness measurements in patients who develop hepatocellular carcinoma after clearance of the hepatitis C virus |
title_short | Role of liver stiffness measurements in patients who develop hepatocellular carcinoma after clearance of the hepatitis C virus |
title_sort | role of liver stiffness measurements in patients who develop hepatocellular carcinoma after clearance of the hepatitis c virus |
topic | Original Article–Gastroenterology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038899/ https://www.ncbi.nlm.nih.gov/pubmed/35129720 http://dx.doi.org/10.1007/s10396-021-01188-x |
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