A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2

Respiratory tract vaccination has an advantage of needle-free delivery and induction of mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human parainfluenza virus type 3 vector to generate constructs expressing the full spike (S) protein of SARS-CoV-2, its S1 subunit, or the re...

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Detalles Bibliográficos
Autores principales: Ilinykh, Philipp A., Periasamy, Sivakumar, Huang, Kai, Kuzmina, Natalia A., Ramanathan, Palaniappan, Meyer, Michelle N., Mire, Chad E., Kuzmin, Ivan V., Bharaj, Preeti, Endsley, Jessica R., Chikina, Maria, Sealfon, Stuart C., Widen, Steven G., Endsley, Mark A., Bukreyev, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038905/
https://www.ncbi.nlm.nih.gov/pubmed/35468973
http://dx.doi.org/10.1038/s41541-022-00471-3

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