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Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia

The subthalamic nucleus projects to the external and internal pallidum, the modulatory and output nuclei of the basal ganglia, respectively, and plays an indispensable role in controlling voluntary movements. However, the precise mechanism by which the subthalamic nucleus controls pallidal activity...

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Autores principales: Hasegawa, Taku, Chiken, Satomi, Kobayashi, Kenta, Nambu, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038919/
https://www.ncbi.nlm.nih.gov/pubmed/35468893
http://dx.doi.org/10.1038/s41467-022-29750-2
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author Hasegawa, Taku
Chiken, Satomi
Kobayashi, Kenta
Nambu, Atsushi
author_facet Hasegawa, Taku
Chiken, Satomi
Kobayashi, Kenta
Nambu, Atsushi
author_sort Hasegawa, Taku
collection PubMed
description The subthalamic nucleus projects to the external and internal pallidum, the modulatory and output nuclei of the basal ganglia, respectively, and plays an indispensable role in controlling voluntary movements. However, the precise mechanism by which the subthalamic nucleus controls pallidal activity and movements remains elusive. Here, we utilize chemogenetics to reversibly reduce neural activity of the motor subregion of the subthalamic nucleus in three macaque monkeys (Macaca fuscata, both sexes) during a reaching task. Systemic administration of chemogenetic ligands prolongs movement time and increases spike train variability in the pallidum, but only slightly affects firing rate modulations. Across-trial analyses reveal that the irregular discharges in the pallidum coincides with prolonged movement time. Reduction of subthalamic activity also induces excessive abnormal movements in the contralateral forelimb, which are preceded by subthalamic and pallidal phasic activity changes. Our results suggest that the subthalamic nucleus stabilizes pallidal spike trains and achieves stable movements.
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spelling pubmed-90389192022-04-28 Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia Hasegawa, Taku Chiken, Satomi Kobayashi, Kenta Nambu, Atsushi Nat Commun Article The subthalamic nucleus projects to the external and internal pallidum, the modulatory and output nuclei of the basal ganglia, respectively, and plays an indispensable role in controlling voluntary movements. However, the precise mechanism by which the subthalamic nucleus controls pallidal activity and movements remains elusive. Here, we utilize chemogenetics to reversibly reduce neural activity of the motor subregion of the subthalamic nucleus in three macaque monkeys (Macaca fuscata, both sexes) during a reaching task. Systemic administration of chemogenetic ligands prolongs movement time and increases spike train variability in the pallidum, but only slightly affects firing rate modulations. Across-trial analyses reveal that the irregular discharges in the pallidum coincides with prolonged movement time. Reduction of subthalamic activity also induces excessive abnormal movements in the contralateral forelimb, which are preceded by subthalamic and pallidal phasic activity changes. Our results suggest that the subthalamic nucleus stabilizes pallidal spike trains and achieves stable movements. Nature Publishing Group UK 2022-04-25 /pmc/articles/PMC9038919/ /pubmed/35468893 http://dx.doi.org/10.1038/s41467-022-29750-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hasegawa, Taku
Chiken, Satomi
Kobayashi, Kenta
Nambu, Atsushi
Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia
title Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia
title_full Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia
title_fullStr Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia
title_full_unstemmed Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia
title_short Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia
title_sort subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9038919/
https://www.ncbi.nlm.nih.gov/pubmed/35468893
http://dx.doi.org/10.1038/s41467-022-29750-2
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