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Proteomics in thrombosis research

A State of the Art lecture titled “Proteomics in Thrombosis Research” was presented at the ISTH Congress in 2021. In clinical practice, there is a need for improved plasma biomarker‐based tools for diagnosis and risk prediction of venous thromboembolism (VTE). Analysis of blood, to identify plasma p...

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Autores principales: Edfors, Fredrik, Iglesias, Maria Jesus, Butler, Lynn M., Odeberg, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039028/
https://www.ncbi.nlm.nih.gov/pubmed/35494505
http://dx.doi.org/10.1002/rth2.12706
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author Edfors, Fredrik
Iglesias, Maria Jesus
Butler, Lynn M.
Odeberg, Jacob
author_facet Edfors, Fredrik
Iglesias, Maria Jesus
Butler, Lynn M.
Odeberg, Jacob
author_sort Edfors, Fredrik
collection PubMed
description A State of the Art lecture titled “Proteomics in Thrombosis Research” was presented at the ISTH Congress in 2021. In clinical practice, there is a need for improved plasma biomarker‐based tools for diagnosis and risk prediction of venous thromboembolism (VTE). Analysis of blood, to identify plasma proteins with potential utility for such tools, could enable an individualized approach to treatment and prevention. Technological advances to study the plasma proteome on a large scale allows broad screening for the identification of novel plasma biomarkers, both by targeted and nontargeted proteomics methods. However, assay limitations need to be considered when interpreting results, with orthogonal validation required before conclusions are drawn. Here, we review and provide perspectives on the application of affinity‐ and mass spectrometry‐based methods for the identification and analysis of plasma protein biomarkers, with potential application in the field of VTE. We also provide a future perspective on discovery strategies and emerging technologies for targeted proteomics in thrombosis research. Finally, we summarize relevant new data on this topic, presented during the 2021 ISTH Congress.
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spelling pubmed-90390282022-04-27 Proteomics in thrombosis research Edfors, Fredrik Iglesias, Maria Jesus Butler, Lynn M. Odeberg, Jacob Res Pract Thromb Haemost State of the Art Isth 2021 A State of the Art lecture titled “Proteomics in Thrombosis Research” was presented at the ISTH Congress in 2021. In clinical practice, there is a need for improved plasma biomarker‐based tools for diagnosis and risk prediction of venous thromboembolism (VTE). Analysis of blood, to identify plasma proteins with potential utility for such tools, could enable an individualized approach to treatment and prevention. Technological advances to study the plasma proteome on a large scale allows broad screening for the identification of novel plasma biomarkers, both by targeted and nontargeted proteomics methods. However, assay limitations need to be considered when interpreting results, with orthogonal validation required before conclusions are drawn. Here, we review and provide perspectives on the application of affinity‐ and mass spectrometry‐based methods for the identification and analysis of plasma protein biomarkers, with potential application in the field of VTE. We also provide a future perspective on discovery strategies and emerging technologies for targeted proteomics in thrombosis research. Finally, we summarize relevant new data on this topic, presented during the 2021 ISTH Congress. John Wiley and Sons Inc. 2022-04-25 /pmc/articles/PMC9039028/ /pubmed/35494505 http://dx.doi.org/10.1002/rth2.12706 Text en © 2022 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle State of the Art Isth 2021
Edfors, Fredrik
Iglesias, Maria Jesus
Butler, Lynn M.
Odeberg, Jacob
Proteomics in thrombosis research
title Proteomics in thrombosis research
title_full Proteomics in thrombosis research
title_fullStr Proteomics in thrombosis research
title_full_unstemmed Proteomics in thrombosis research
title_short Proteomics in thrombosis research
title_sort proteomics in thrombosis research
topic State of the Art Isth 2021
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039028/
https://www.ncbi.nlm.nih.gov/pubmed/35494505
http://dx.doi.org/10.1002/rth2.12706
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