Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairment

Alzheimer’s disease (AD) is the prevalent cause of dementia in the ageing world population. Apolipoprotein E4 (ApoE4) allele is the key genetic risk factor for AD, although the mechanisms linking ApoE4 with neurocognitive impairments and aberrant metabolism remains to be fully characterised. We disc...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Manman, Gong, Wenliang, Zhang, Dianjun, Ji, Ming, Chen, Binjie, Chen, Beina, Li, Xinyu, Zhou, Yuefei, Dong, Chengyi, Wen, Gehua, Zhan, Xiaoni, Wu, Xiafang, Cui, Lulu, Feng, Yuliang, Wang, Siman, Yuan, Huiya, Xu, Enyu, Xia, Maosheng, Verkhratsky, Alexei, Li, Baoman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039072/
https://www.ncbi.nlm.nih.gov/pubmed/35468877
http://dx.doi.org/10.1038/s41419-022-04858-x

Ejemplares similares

Ejemplares similares