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Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats

BACKGROUND AND AIM: The present study evaluates the antidiabetic effects of aqueous (CPAQ) and methanolic (CPME) extract of Costus pictus D. Don singly and/or in combination with metformin in alloxan-induced diabetic rats. EXPERIMENTAL PROCEDURE: CPAQ and CPME (400 mg/kg dose), metformin (120 mg/kg)...

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Autores principales: Naik, Ami, Adeyemi, Sherif Babatunde, Vyas, Bhavin, Krishnamurthy, Ramar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039101/
https://www.ncbi.nlm.nih.gov/pubmed/35493313
http://dx.doi.org/10.1016/j.jtcme.2021.08.007
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author Naik, Ami
Adeyemi, Sherif Babatunde
Vyas, Bhavin
Krishnamurthy, Ramar
author_facet Naik, Ami
Adeyemi, Sherif Babatunde
Vyas, Bhavin
Krishnamurthy, Ramar
author_sort Naik, Ami
collection PubMed
description BACKGROUND AND AIM: The present study evaluates the antidiabetic effects of aqueous (CPAQ) and methanolic (CPME) extract of Costus pictus D. Don singly and/or in combination with metformin in alloxan-induced diabetic rats. EXPERIMENTAL PROCEDURE: CPAQ and CPME (400 mg/kg dose), metformin (120 mg/kg) and two different combinations of plant extracts and metformin (200 + 60 mg/kg and 400 mg/kg + 60 mg/kg) were orally given to alloxan-induced diabetic rats for 21 days. At 0, 7, 14, and 21 days, body weight and blood glucose levels were measured. RESULTS AND CONCLUSION: After 21 days of treatment, biochemical profiling and histopathology analysis were carried out. CPAQ and CPME, when administrated separately, could decrease blood glucose levels (P ≤ 0.05). CPME showed more promising results (P ≤ 0.05) compared to the diabetic control group. Extracts co-administrated with metformin showed dose-dependent significant recovery of hypoglycemic activity of metformin. Fasting blood glucose levels, body weight, protein, and lipid profile of the treatment group were compared to the diabetic and normal control groups. Animal groups co-administered with CPME and metformin showed more significant effects on the recovery of tissue damages. The synergistic effect of plant extracts with metformin has positive effects on all the parameters and enhanced the efficiency and reduction of blood glucose levels.
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spelling pubmed-90391012022-04-27 Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats Naik, Ami Adeyemi, Sherif Babatunde Vyas, Bhavin Krishnamurthy, Ramar J Tradit Complement Med Article BACKGROUND AND AIM: The present study evaluates the antidiabetic effects of aqueous (CPAQ) and methanolic (CPME) extract of Costus pictus D. Don singly and/or in combination with metformin in alloxan-induced diabetic rats. EXPERIMENTAL PROCEDURE: CPAQ and CPME (400 mg/kg dose), metformin (120 mg/kg) and two different combinations of plant extracts and metformin (200 + 60 mg/kg and 400 mg/kg + 60 mg/kg) were orally given to alloxan-induced diabetic rats for 21 days. At 0, 7, 14, and 21 days, body weight and blood glucose levels were measured. RESULTS AND CONCLUSION: After 21 days of treatment, biochemical profiling and histopathology analysis were carried out. CPAQ and CPME, when administrated separately, could decrease blood glucose levels (P ≤ 0.05). CPME showed more promising results (P ≤ 0.05) compared to the diabetic control group. Extracts co-administrated with metformin showed dose-dependent significant recovery of hypoglycemic activity of metformin. Fasting blood glucose levels, body weight, protein, and lipid profile of the treatment group were compared to the diabetic and normal control groups. Animal groups co-administered with CPME and metformin showed more significant effects on the recovery of tissue damages. The synergistic effect of plant extracts with metformin has positive effects on all the parameters and enhanced the efficiency and reduction of blood glucose levels. Elsevier 2021-08-12 /pmc/articles/PMC9039101/ /pubmed/35493313 http://dx.doi.org/10.1016/j.jtcme.2021.08.007 Text en © 2021 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Naik, Ami
Adeyemi, Sherif Babatunde
Vyas, Bhavin
Krishnamurthy, Ramar
Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats
title Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats
title_full Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats
title_fullStr Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats
title_full_unstemmed Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats
title_short Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats
title_sort effect of co-administration of metformin and extracts of costus pictus d.don leaves on alloxan-induced diabetes in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039101/
https://www.ncbi.nlm.nih.gov/pubmed/35493313
http://dx.doi.org/10.1016/j.jtcme.2021.08.007
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