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Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance

BACKGROUND AND AIM: Common chickweed (Stellaria media) tea has traditionally been applied for treatment of various metabolic diseases including diabetes in folk medicine; however, experimental evidence to support this practice is lacking. Therefore, we aimed to assess the effect of Stellaria media t...

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Autores principales: Demján, Virág, Sója, Andrea, Kiss, Tivadar, Fejes, Alexandra, Gausz, Flóra Diána, Szűcs, Gergő, Siska, Andrea, Földesi, Imre, Tengölics, Roland, Darula, Zsuzsanna, Csupor, Dezső, Pipicz, Márton, Csont, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039105/
https://www.ncbi.nlm.nih.gov/pubmed/35493309
http://dx.doi.org/10.1016/j.jtcme.2021.08.003
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author Demján, Virág
Sója, Andrea
Kiss, Tivadar
Fejes, Alexandra
Gausz, Flóra Diána
Szűcs, Gergő
Siska, Andrea
Földesi, Imre
Tengölics, Roland
Darula, Zsuzsanna
Csupor, Dezső
Pipicz, Márton
Csont, Tamás
author_facet Demján, Virág
Sója, Andrea
Kiss, Tivadar
Fejes, Alexandra
Gausz, Flóra Diána
Szűcs, Gergő
Siska, Andrea
Földesi, Imre
Tengölics, Roland
Darula, Zsuzsanna
Csupor, Dezső
Pipicz, Márton
Csont, Tamás
author_sort Demján, Virág
collection PubMed
description BACKGROUND AND AIM: Common chickweed (Stellaria media) tea has traditionally been applied for treatment of various metabolic diseases including diabetes in folk medicine; however, experimental evidence to support this practice is lacking. Therefore, we aimed to assess the effect of Stellaria media tea on glucose homeostasis and cardiac performance in a rat model of diabetes. EXPERIMENTAL PROCEDURE: Hot water extract of Stellaria media herb were analyzed and used in this study, where diabetes was induced by fructose-enriched diet supplemented with a single injection of streptozotocin. Half of the animals received Stellaria media tea (100 mg/kg) by oral gavage. At the end of the 20-week experimental period, blood samples were collected and isolated working heart perfusions were performed. RESULTS AND CONCLUSION: Compared to the animals receiving standard chow, serum fasting glucose level was increased and glucose tolerance was diminished in diabetic rats. Stellaria media tea did not affect significantly fasting hyperglycemia and glucose intolerance; however, it attenuated diabetes-induced deterioration of cardiac output and cardiac work. Analysis of the chemical composition of Stellaria media tea suggested the presence of rutin and various apigenin glycosides which have been reported to alleviate diabetic cardiomyopathy. Moreover, Stellaria media prevented diabetes-induced increase in cardiac STAT3 phosphorylation. We demonstrated for the first time that Stellaria media tea may beneficially affect cardiac dysfunction induced by diabetes without improvement of glucose homeostasis. Rutin and/or apigenin glycosides as well as modulation of STAT3 signaling may be implicated in the protection of Stellaria media tea against diabetic cardiomyopathy.
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spelling pubmed-90391052022-04-27 Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance Demján, Virág Sója, Andrea Kiss, Tivadar Fejes, Alexandra Gausz, Flóra Diána Szűcs, Gergő Siska, Andrea Földesi, Imre Tengölics, Roland Darula, Zsuzsanna Csupor, Dezső Pipicz, Márton Csont, Tamás J Tradit Complement Med Article BACKGROUND AND AIM: Common chickweed (Stellaria media) tea has traditionally been applied for treatment of various metabolic diseases including diabetes in folk medicine; however, experimental evidence to support this practice is lacking. Therefore, we aimed to assess the effect of Stellaria media tea on glucose homeostasis and cardiac performance in a rat model of diabetes. EXPERIMENTAL PROCEDURE: Hot water extract of Stellaria media herb were analyzed and used in this study, where diabetes was induced by fructose-enriched diet supplemented with a single injection of streptozotocin. Half of the animals received Stellaria media tea (100 mg/kg) by oral gavage. At the end of the 20-week experimental period, blood samples were collected and isolated working heart perfusions were performed. RESULTS AND CONCLUSION: Compared to the animals receiving standard chow, serum fasting glucose level was increased and glucose tolerance was diminished in diabetic rats. Stellaria media tea did not affect significantly fasting hyperglycemia and glucose intolerance; however, it attenuated diabetes-induced deterioration of cardiac output and cardiac work. Analysis of the chemical composition of Stellaria media tea suggested the presence of rutin and various apigenin glycosides which have been reported to alleviate diabetic cardiomyopathy. Moreover, Stellaria media prevented diabetes-induced increase in cardiac STAT3 phosphorylation. We demonstrated for the first time that Stellaria media tea may beneficially affect cardiac dysfunction induced by diabetes without improvement of glucose homeostasis. Rutin and/or apigenin glycosides as well as modulation of STAT3 signaling may be implicated in the protection of Stellaria media tea against diabetic cardiomyopathy. Elsevier 2021-08-10 /pmc/articles/PMC9039105/ /pubmed/35493309 http://dx.doi.org/10.1016/j.jtcme.2021.08.003 Text en © 2021 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Demján, Virág
Sója, Andrea
Kiss, Tivadar
Fejes, Alexandra
Gausz, Flóra Diána
Szűcs, Gergő
Siska, Andrea
Földesi, Imre
Tengölics, Roland
Darula, Zsuzsanna
Csupor, Dezső
Pipicz, Márton
Csont, Tamás
Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance
title Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance
title_full Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance
title_fullStr Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance
title_full_unstemmed Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance
title_short Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance
title_sort stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039105/
https://www.ncbi.nlm.nih.gov/pubmed/35493309
http://dx.doi.org/10.1016/j.jtcme.2021.08.003
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