Cargando…

Association of Homocysteine Levels With Medial Temporal Lobe Atrophy Among Carriers and Non-carriers of APOE ε4 in MCI Subjects

BACKGROUND: Different clinical subtypes of mild cognitive impairment (MCI) involve heterogeneous underlying etiologies. This study investigated the association between demographics, neuropsychological performance, apolipoprotein E (APOE) genotype and magnetic resonance imaging (MRI) measures in pati...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Jun, Ma, Ling-Yun, Man, FengYuan, Zhang, Guili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039208/
https://www.ncbi.nlm.nih.gov/pubmed/35492717
http://dx.doi.org/10.3389/fpsyt.2022.823605
_version_ 1784694074556547072
author Ma, Jun
Ma, Ling-Yun
Man, FengYuan
Zhang, Guili
author_facet Ma, Jun
Ma, Ling-Yun
Man, FengYuan
Zhang, Guili
author_sort Ma, Jun
collection PubMed
description BACKGROUND: Different clinical subtypes of mild cognitive impairment (MCI) involve heterogeneous underlying etiologies. This study investigated the association between demographics, neuropsychological performance, apolipoprotein E (APOE) genotype and magnetic resonance imaging (MRI) measures in patients with MCI (amnestic [aMCI] and non-amnestic [naMCI]). METHODS: This case–control study included 130 aMCI patients, 58 naMCI patients, and 1,106 healthy controls (HCs). APOE genotypes, medial temporal lobe atrophy (MTA), neurological evaluation results, and white matter hyperintensities (WMH) were investigated. Serum folate and vitamin B12 concentrations were analyzed by radioimmunoassay, and plasma hyperhomocysteinemia (Hcy) was assessed by a high-performance liquid chromatography-fluorescence method. RESULTS: Serum folate levels were significantly lower, but plasma Hcy levels were higher, in patients with aMCI and naMCI than in healthy controls. There were significantly higher MTA scores in the aMCI group than the healthy control group. Multiple linear regression showed that serum Hcy and folate concentrations were positively associated with MTA (p < 0.05), while APOE4 showed a significant negative association with MTA in the aMCI group (p < 0.01). In addition, moderate/severe WMH showed a significant negative association with MTA in the naMCI and HC groups (p < 0.01). CONCLUSION: The combined presence of APOE4 and Hcy is associated with aMCI in elderly individuals, while moderate/severe WMH is related to naMCI, which suggests etiological differences across MCI subtypes.
format Online
Article
Text
id pubmed-9039208
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90392082022-04-27 Association of Homocysteine Levels With Medial Temporal Lobe Atrophy Among Carriers and Non-carriers of APOE ε4 in MCI Subjects Ma, Jun Ma, Ling-Yun Man, FengYuan Zhang, Guili Front Psychiatry Psychiatry BACKGROUND: Different clinical subtypes of mild cognitive impairment (MCI) involve heterogeneous underlying etiologies. This study investigated the association between demographics, neuropsychological performance, apolipoprotein E (APOE) genotype and magnetic resonance imaging (MRI) measures in patients with MCI (amnestic [aMCI] and non-amnestic [naMCI]). METHODS: This case–control study included 130 aMCI patients, 58 naMCI patients, and 1,106 healthy controls (HCs). APOE genotypes, medial temporal lobe atrophy (MTA), neurological evaluation results, and white matter hyperintensities (WMH) were investigated. Serum folate and vitamin B12 concentrations were analyzed by radioimmunoassay, and plasma hyperhomocysteinemia (Hcy) was assessed by a high-performance liquid chromatography-fluorescence method. RESULTS: Serum folate levels were significantly lower, but plasma Hcy levels were higher, in patients with aMCI and naMCI than in healthy controls. There were significantly higher MTA scores in the aMCI group than the healthy control group. Multiple linear regression showed that serum Hcy and folate concentrations were positively associated with MTA (p < 0.05), while APOE4 showed a significant negative association with MTA in the aMCI group (p < 0.01). In addition, moderate/severe WMH showed a significant negative association with MTA in the naMCI and HC groups (p < 0.01). CONCLUSION: The combined presence of APOE4 and Hcy is associated with aMCI in elderly individuals, while moderate/severe WMH is related to naMCI, which suggests etiological differences across MCI subtypes. Frontiers Media S.A. 2022-04-12 /pmc/articles/PMC9039208/ /pubmed/35492717 http://dx.doi.org/10.3389/fpsyt.2022.823605 Text en Copyright © 2022 Ma, Ma, Man and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Ma, Jun
Ma, Ling-Yun
Man, FengYuan
Zhang, Guili
Association of Homocysteine Levels With Medial Temporal Lobe Atrophy Among Carriers and Non-carriers of APOE ε4 in MCI Subjects
title Association of Homocysteine Levels With Medial Temporal Lobe Atrophy Among Carriers and Non-carriers of APOE ε4 in MCI Subjects
title_full Association of Homocysteine Levels With Medial Temporal Lobe Atrophy Among Carriers and Non-carriers of APOE ε4 in MCI Subjects
title_fullStr Association of Homocysteine Levels With Medial Temporal Lobe Atrophy Among Carriers and Non-carriers of APOE ε4 in MCI Subjects
title_full_unstemmed Association of Homocysteine Levels With Medial Temporal Lobe Atrophy Among Carriers and Non-carriers of APOE ε4 in MCI Subjects
title_short Association of Homocysteine Levels With Medial Temporal Lobe Atrophy Among Carriers and Non-carriers of APOE ε4 in MCI Subjects
title_sort association of homocysteine levels with medial temporal lobe atrophy among carriers and non-carriers of apoe ε4 in mci subjects
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039208/
https://www.ncbi.nlm.nih.gov/pubmed/35492717
http://dx.doi.org/10.3389/fpsyt.2022.823605
work_keys_str_mv AT majun associationofhomocysteinelevelswithmedialtemporallobeatrophyamongcarriersandnoncarriersofapoee4inmcisubjects
AT malingyun associationofhomocysteinelevelswithmedialtemporallobeatrophyamongcarriersandnoncarriersofapoee4inmcisubjects
AT manfengyuan associationofhomocysteinelevelswithmedialtemporallobeatrophyamongcarriersandnoncarriersofapoee4inmcisubjects
AT zhangguili associationofhomocysteinelevelswithmedialtemporallobeatrophyamongcarriersandnoncarriersofapoee4inmcisubjects