Cargando…

Clinical Basis for Creating an Osseointegrated Neural Interface

As technology continues to improve within the neuroprosthetic landscape, there has been a paradigm shift in the approach to amputation and surgical implementation of haptic neural prosthesis for limb restoration. The Osseointegrated Neural Interface (ONI) is a proposed solution involving the transpo...

Descripción completa

Detalles Bibliográficos
Autores principales: Karczewski, Alison M., Zeng, Weifeng, Stratchko, Lindsay M., Bachus, Kent N., Poore, Samuel O., Dingle, Aaron M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039253/
https://www.ncbi.nlm.nih.gov/pubmed/35495044
http://dx.doi.org/10.3389/fnins.2022.828593
_version_ 1784694085309693952
author Karczewski, Alison M.
Zeng, Weifeng
Stratchko, Lindsay M.
Bachus, Kent N.
Poore, Samuel O.
Dingle, Aaron M.
author_facet Karczewski, Alison M.
Zeng, Weifeng
Stratchko, Lindsay M.
Bachus, Kent N.
Poore, Samuel O.
Dingle, Aaron M.
author_sort Karczewski, Alison M.
collection PubMed
description As technology continues to improve within the neuroprosthetic landscape, there has been a paradigm shift in the approach to amputation and surgical implementation of haptic neural prosthesis for limb restoration. The Osseointegrated Neural Interface (ONI) is a proposed solution involving the transposition of terminal nerves into the medullary canal of long bones. This design combines concepts of neuroma formation and prevention with osseointegration to provide a stable environment for conduction of neural signals for sophisticated prosthetic control. While this concept has previously been explored in animal models, it has yet to be explored in humans. This anatomic study used three upper limb and three lower limb cadavers to assess the clinical feasibility of creating an ONI in humans. Anatomical measurement of the major peripheral nerves- circumference, length, and depth- were performed as they are critical for electrode design and rerouting of the nerves into the long bones. CT imaging was used for morphologic bone evaluation and virtual implantation of two osseointegrated implants were performed to assess the amount of residual medullary space available for housing the neural interfacing hardware. Use of a small stem osseointegrated implant was found to reduce bone removal and provide more intramedullary space than a traditional implant; however, the higher the amputation site, the less medullary space was available regardless of implant type. Thus the stability of the endoprosthesis must be maximized while still maintaining enough residual space for the interface components. The results from this study provide an anatomic basis required for establishing a clinically applicable ONI in humans. They may serve as a guide for surgical implementation of an osseointegrated endoprosthesis with intramedullary electrodes for prosthetic control.
format Online
Article
Text
id pubmed-9039253
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90392532022-04-27 Clinical Basis for Creating an Osseointegrated Neural Interface Karczewski, Alison M. Zeng, Weifeng Stratchko, Lindsay M. Bachus, Kent N. Poore, Samuel O. Dingle, Aaron M. Front Neurosci Neuroscience As technology continues to improve within the neuroprosthetic landscape, there has been a paradigm shift in the approach to amputation and surgical implementation of haptic neural prosthesis for limb restoration. The Osseointegrated Neural Interface (ONI) is a proposed solution involving the transposition of terminal nerves into the medullary canal of long bones. This design combines concepts of neuroma formation and prevention with osseointegration to provide a stable environment for conduction of neural signals for sophisticated prosthetic control. While this concept has previously been explored in animal models, it has yet to be explored in humans. This anatomic study used three upper limb and three lower limb cadavers to assess the clinical feasibility of creating an ONI in humans. Anatomical measurement of the major peripheral nerves- circumference, length, and depth- were performed as they are critical for electrode design and rerouting of the nerves into the long bones. CT imaging was used for morphologic bone evaluation and virtual implantation of two osseointegrated implants were performed to assess the amount of residual medullary space available for housing the neural interfacing hardware. Use of a small stem osseointegrated implant was found to reduce bone removal and provide more intramedullary space than a traditional implant; however, the higher the amputation site, the less medullary space was available regardless of implant type. Thus the stability of the endoprosthesis must be maximized while still maintaining enough residual space for the interface components. The results from this study provide an anatomic basis required for establishing a clinically applicable ONI in humans. They may serve as a guide for surgical implementation of an osseointegrated endoprosthesis with intramedullary electrodes for prosthetic control. Frontiers Media S.A. 2022-04-12 /pmc/articles/PMC9039253/ /pubmed/35495044 http://dx.doi.org/10.3389/fnins.2022.828593 Text en Copyright © 2022 Karczewski, Zeng, Stratchko, Bachus, Poore and Dingle. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Karczewski, Alison M.
Zeng, Weifeng
Stratchko, Lindsay M.
Bachus, Kent N.
Poore, Samuel O.
Dingle, Aaron M.
Clinical Basis for Creating an Osseointegrated Neural Interface
title Clinical Basis for Creating an Osseointegrated Neural Interface
title_full Clinical Basis for Creating an Osseointegrated Neural Interface
title_fullStr Clinical Basis for Creating an Osseointegrated Neural Interface
title_full_unstemmed Clinical Basis for Creating an Osseointegrated Neural Interface
title_short Clinical Basis for Creating an Osseointegrated Neural Interface
title_sort clinical basis for creating an osseointegrated neural interface
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039253/
https://www.ncbi.nlm.nih.gov/pubmed/35495044
http://dx.doi.org/10.3389/fnins.2022.828593
work_keys_str_mv AT karczewskialisonm clinicalbasisforcreatinganosseointegratedneuralinterface
AT zengweifeng clinicalbasisforcreatinganosseointegratedneuralinterface
AT stratchkolindsaym clinicalbasisforcreatinganosseointegratedneuralinterface
AT bachuskentn clinicalbasisforcreatinganosseointegratedneuralinterface
AT pooresamuelo clinicalbasisforcreatinganosseointegratedneuralinterface
AT dingleaaronm clinicalbasisforcreatinganosseointegratedneuralinterface