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The Association Between Dietary Inflammatory Index and Cognitive Performance in Older Adults Aged 60 Years and Older

BACKGROUND: Neuroinflammation has been linked to the development of cognitive performance. Epidemiological evidence on dietary inflammatory potential and cognitive performance is scarce. We evaluated the association between dietary inflammatory index (DII) and cognitive performance in older adults....

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Autores principales: Song, Wenlei, Feng, Yijun, Gong, Zonglin, Tian, Changwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039302/
https://www.ncbi.nlm.nih.gov/pubmed/35495906
http://dx.doi.org/10.3389/fnut.2022.748000
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author Song, Wenlei
Feng, Yijun
Gong, Zonglin
Tian, Changwei
author_facet Song, Wenlei
Feng, Yijun
Gong, Zonglin
Tian, Changwei
author_sort Song, Wenlei
collection PubMed
description BACKGROUND: Neuroinflammation has been linked to the development of cognitive performance. Epidemiological evidence on dietary inflammatory potential and cognitive performance is scarce. We evaluated the association between dietary inflammatory index (DII) and cognitive performance in older adults. METHODS: This study included adults aged 60 years or older from the 2011–2014 National Health and Nutrition Examination Survey. The DII scores were calculated based on 27 nutritional parameters. Cognitive performance was assessed with four cognitive tests: the Digit Symbol Substitution Test (DSST, n = 2,780), the Consortium to Establish a Registry for Alzheimer’s Disease Word Learning (CERAD-WL, n = 2,859) and Delayed Recall (CERAD-DR, n = 2,857), and the Animal Fluency (AF, n = 2,844) tests. Restricted cubic splines and logistic regression were adopted to assess the associations. RESULTS: Comparing the highest to lowest tertile of DII scores, the odds ratio (95% CI) of lower cognitive functioning was 1.97 (1.08–3.58) [P-trend = 0.02, per 1 unit increment: 1.17 (1.01–1.38)] on DSST, 1.24 (0.87–1.76) [P-trend = 0.24, per 1 unit increment: 1.09 (0.96–1.23)] on CERAD-WL, 0.93 (0.57–1.51) [P-trend = 0.74, per 1 unit increment: 1.02 (0.87–1.20)] on CERAD-DR, and 1.76 (1.30–2.37) [P-trend < 0.01, per 1 unit increment: 1.17 (1.05–1.29)] on AF. The above-mentioned associations were observed in both men and women. In non-linear dose–response analysis, the association between DII and lower cognitive functioning was not significant at lower DII scores up to 3.0, after which the association was significant and the curve rose steeply. CONCLUSION: Higher DII is associated with lower scores on DSST and AF tests in older adults.
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spelling pubmed-90393022022-04-27 The Association Between Dietary Inflammatory Index and Cognitive Performance in Older Adults Aged 60 Years and Older Song, Wenlei Feng, Yijun Gong, Zonglin Tian, Changwei Front Nutr Nutrition BACKGROUND: Neuroinflammation has been linked to the development of cognitive performance. Epidemiological evidence on dietary inflammatory potential and cognitive performance is scarce. We evaluated the association between dietary inflammatory index (DII) and cognitive performance in older adults. METHODS: This study included adults aged 60 years or older from the 2011–2014 National Health and Nutrition Examination Survey. The DII scores were calculated based on 27 nutritional parameters. Cognitive performance was assessed with four cognitive tests: the Digit Symbol Substitution Test (DSST, n = 2,780), the Consortium to Establish a Registry for Alzheimer’s Disease Word Learning (CERAD-WL, n = 2,859) and Delayed Recall (CERAD-DR, n = 2,857), and the Animal Fluency (AF, n = 2,844) tests. Restricted cubic splines and logistic regression were adopted to assess the associations. RESULTS: Comparing the highest to lowest tertile of DII scores, the odds ratio (95% CI) of lower cognitive functioning was 1.97 (1.08–3.58) [P-trend = 0.02, per 1 unit increment: 1.17 (1.01–1.38)] on DSST, 1.24 (0.87–1.76) [P-trend = 0.24, per 1 unit increment: 1.09 (0.96–1.23)] on CERAD-WL, 0.93 (0.57–1.51) [P-trend = 0.74, per 1 unit increment: 1.02 (0.87–1.20)] on CERAD-DR, and 1.76 (1.30–2.37) [P-trend < 0.01, per 1 unit increment: 1.17 (1.05–1.29)] on AF. The above-mentioned associations were observed in both men and women. In non-linear dose–response analysis, the association between DII and lower cognitive functioning was not significant at lower DII scores up to 3.0, after which the association was significant and the curve rose steeply. CONCLUSION: Higher DII is associated with lower scores on DSST and AF tests in older adults. Frontiers Media S.A. 2022-04-12 /pmc/articles/PMC9039302/ /pubmed/35495906 http://dx.doi.org/10.3389/fnut.2022.748000 Text en Copyright © 2022 Song, Feng, Gong and Tian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Song, Wenlei
Feng, Yijun
Gong, Zonglin
Tian, Changwei
The Association Between Dietary Inflammatory Index and Cognitive Performance in Older Adults Aged 60 Years and Older
title The Association Between Dietary Inflammatory Index and Cognitive Performance in Older Adults Aged 60 Years and Older
title_full The Association Between Dietary Inflammatory Index and Cognitive Performance in Older Adults Aged 60 Years and Older
title_fullStr The Association Between Dietary Inflammatory Index and Cognitive Performance in Older Adults Aged 60 Years and Older
title_full_unstemmed The Association Between Dietary Inflammatory Index and Cognitive Performance in Older Adults Aged 60 Years and Older
title_short The Association Between Dietary Inflammatory Index and Cognitive Performance in Older Adults Aged 60 Years and Older
title_sort association between dietary inflammatory index and cognitive performance in older adults aged 60 years and older
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039302/
https://www.ncbi.nlm.nih.gov/pubmed/35495906
http://dx.doi.org/10.3389/fnut.2022.748000
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