Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?

Tissue-resident memory T (T(RM)) cells have emerged as immune sentinels that patrol the tissue microenvironment and orchestrate localized antitumor immunity in various solid cancers. Recent studies have revealed that T(RM) cells are key players in cancer immunosurveillance, and their involvement has...

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Autores principales: Abdeljaoued, Syrine, Arfa, Sara, Kroemer, Marie, Ben Khelil, Myriam, Vienot, Angélique, Heyd, Bruno, Loyon, Romain, Doussot, Alexandre, Borg, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039405/
https://www.ncbi.nlm.nih.gov/pubmed/35470231
http://dx.doi.org/10.1136/jitc-2021-003472
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author Abdeljaoued, Syrine
Arfa, Sara
Kroemer, Marie
Ben Khelil, Myriam
Vienot, Angélique
Heyd, Bruno
Loyon, Romain
Doussot, Alexandre
Borg, Christophe
author_facet Abdeljaoued, Syrine
Arfa, Sara
Kroemer, Marie
Ben Khelil, Myriam
Vienot, Angélique
Heyd, Bruno
Loyon, Romain
Doussot, Alexandre
Borg, Christophe
author_sort Abdeljaoued, Syrine
collection PubMed
description Tissue-resident memory T (T(RM)) cells have emerged as immune sentinels that patrol the tissue microenvironment and orchestrate localized antitumor immunity in various solid cancers. Recent studies have revealed that T(RM) cells are key players in cancer immunosurveillance, and their involvement has been linked to favorable responses to immunotherapy as well as general better clinical outcome in cancer patients. In this review, we provide an overview of the major advances and recent findings regarding T(RM) cells phenotype, transcriptional and epigenetic regulation in cancer with a special focus on gastrointestinal tumors. Finally, we highlight the exciting clinical implication of T(RM) cells in these types of tumors.
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spelling pubmed-90394052022-05-06 Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time? Abdeljaoued, Syrine Arfa, Sara Kroemer, Marie Ben Khelil, Myriam Vienot, Angélique Heyd, Bruno Loyon, Romain Doussot, Alexandre Borg, Christophe J Immunother Cancer Review Tissue-resident memory T (T(RM)) cells have emerged as immune sentinels that patrol the tissue microenvironment and orchestrate localized antitumor immunity in various solid cancers. Recent studies have revealed that T(RM) cells are key players in cancer immunosurveillance, and their involvement has been linked to favorable responses to immunotherapy as well as general better clinical outcome in cancer patients. In this review, we provide an overview of the major advances and recent findings regarding T(RM) cells phenotype, transcriptional and epigenetic regulation in cancer with a special focus on gastrointestinal tumors. Finally, we highlight the exciting clinical implication of T(RM) cells in these types of tumors. BMJ Publishing Group 2022-04-24 /pmc/articles/PMC9039405/ /pubmed/35470231 http://dx.doi.org/10.1136/jitc-2021-003472 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Abdeljaoued, Syrine
Arfa, Sara
Kroemer, Marie
Ben Khelil, Myriam
Vienot, Angélique
Heyd, Bruno
Loyon, Romain
Doussot, Alexandre
Borg, Christophe
Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?
title Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?
title_full Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?
title_fullStr Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?
title_full_unstemmed Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?
title_short Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?
title_sort tissue-resident memory t cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039405/
https://www.ncbi.nlm.nih.gov/pubmed/35470231
http://dx.doi.org/10.1136/jitc-2021-003472
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