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L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults
Cognitive impairment is a prevailing event in hypertensive patients and in frail older adults. Endothelial dysfunction has been shown to underlie both hypertension and cognitive dysfunction. Our hypothesis is that L-Arginine, which is known to ameliorate endothelial dysfunction, could counteract cog...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039514/ https://www.ncbi.nlm.nih.gov/pubmed/35498050 http://dx.doi.org/10.3389/fcvm.2022.868521 |
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author | Mone, Pasquale Pansini, Antonella Jankauskas, Stanislovas S. Varzideh, Fahimeh Kansakar, Urna Lombardi, Angela Trimarco, Valentina Frullone, Salvatore Santulli, Gaetano |
author_facet | Mone, Pasquale Pansini, Antonella Jankauskas, Stanislovas S. Varzideh, Fahimeh Kansakar, Urna Lombardi, Angela Trimarco, Valentina Frullone, Salvatore Santulli, Gaetano |
author_sort | Mone, Pasquale |
collection | PubMed |
description | Cognitive impairment is a prevailing event in hypertensive patients and in frail older adults. Endothelial dysfunction has been shown to underlie both hypertension and cognitive dysfunction. Our hypothesis is that L-Arginine, which is known to ameliorate endothelial dysfunction, could counteract cognitive impairment in a high-risk population of hypertensive frail older adults. We designed a clinical trial to verify the effects of 4-weeks oral supplementation of L-Arginine on global cognitive function of hypertensive frail older patients. The study was successfully completed by 35 frail hypertensive elderly patients assigned to L-Arginine and 37 assigned to placebo. At follow-up, we found a significant difference in the Montreal Cognitive Assessment (MoCA) test score between the L-Arginine treated group and placebo (p: 0.0178). Moreover, we demonstrated that L-Arginine significantly attenuates Angiotensin II-induced mitochondrial oxidative stress in human endothelial cells. In conclusion, our findings indicate for the first time that oral L-Arginine supplementation significantly improves cognitive impairment in frail hypertensive older adults. CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov, identifier: NCT04962841. |
format | Online Article Text |
id | pubmed-9039514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90395142022-04-27 L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults Mone, Pasquale Pansini, Antonella Jankauskas, Stanislovas S. Varzideh, Fahimeh Kansakar, Urna Lombardi, Angela Trimarco, Valentina Frullone, Salvatore Santulli, Gaetano Front Cardiovasc Med Cardiovascular Medicine Cognitive impairment is a prevailing event in hypertensive patients and in frail older adults. Endothelial dysfunction has been shown to underlie both hypertension and cognitive dysfunction. Our hypothesis is that L-Arginine, which is known to ameliorate endothelial dysfunction, could counteract cognitive impairment in a high-risk population of hypertensive frail older adults. We designed a clinical trial to verify the effects of 4-weeks oral supplementation of L-Arginine on global cognitive function of hypertensive frail older patients. The study was successfully completed by 35 frail hypertensive elderly patients assigned to L-Arginine and 37 assigned to placebo. At follow-up, we found a significant difference in the Montreal Cognitive Assessment (MoCA) test score between the L-Arginine treated group and placebo (p: 0.0178). Moreover, we demonstrated that L-Arginine significantly attenuates Angiotensin II-induced mitochondrial oxidative stress in human endothelial cells. In conclusion, our findings indicate for the first time that oral L-Arginine supplementation significantly improves cognitive impairment in frail hypertensive older adults. CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov, identifier: NCT04962841. Frontiers Media S.A. 2022-04-12 /pmc/articles/PMC9039514/ /pubmed/35498050 http://dx.doi.org/10.3389/fcvm.2022.868521 Text en Copyright © 2022 Mone, Pansini, Jankauskas, Varzideh, Kansakar, Lombardi, Trimarco, Frullone and Santulli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Mone, Pasquale Pansini, Antonella Jankauskas, Stanislovas S. Varzideh, Fahimeh Kansakar, Urna Lombardi, Angela Trimarco, Valentina Frullone, Salvatore Santulli, Gaetano L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults |
title | L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults |
title_full | L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults |
title_fullStr | L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults |
title_full_unstemmed | L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults |
title_short | L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults |
title_sort | l-arginine improves cognitive impairment in hypertensive frail older adults |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039514/ https://www.ncbi.nlm.nih.gov/pubmed/35498050 http://dx.doi.org/10.3389/fcvm.2022.868521 |
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