Cargando…

Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation

INTRODUCTION: Leucine-rich repetitive kinase-2 (LRRK2) is a Parkinson's disease-related gene that also participates in many inflammatory diseases. However, the functional role of LRRK2 in cardiovascular disease is not clear. OBJECTIVE: In this study, we aimed to elucidate the role of LRRK2 in c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yuan, Hao, Congqing, Zhang, Wei, Liu, Yuzhou, Guo, Sen, Li, Ran, Peng, Meng, Xu, Yawei, Pei, Xiaoxin, Yang, Haibo, Zhao, Yintao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Basic and Biological Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039674/ https://www.ncbi.nlm.nih.gov/pubmed/35499056 http://dx.doi.org/10.1016/j.jare.2021.07.004

Ejemplares similares

Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies
por: Bravo-San Pedro, José M., et al.
Publicado: (2012)

Leucine Rich Repeat Kinase 2 and Innate Immunity
por: Ahmadi Rastegar, Diba, et al.
Publicado: (2020)

Leucine-rich repeat kinase 2 at a glance
por: Zhu, Christiane, et al.
Publicado: (2023)

Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion
por: Shen, Sandi, et al.
Publicado: (2023)

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
por: Tong, Youren, et al.
Publicado: (2012)

F-box and leucine-rich repeat 6 promotes gastric cancer progression via the promotion of epithelial-mesenchymal transition
por: Meng, Lei, et al.
Publicado: (2023)

An extracellular network of Arabidopsis leucine-rich repeat receptor kinases
por: Smakowska-Luzan, Elwira, et al.
Publicado: (2018)

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
por: Gómez-Suaga, Patricia, et al.
Publicado: (2012)

Leucine-Rich repeat receptor kinases are sporadically distributed in eukaryotic genomes
por: Diévart, Anne, et al.
Publicado: (2011)

Role and mechanism of action of leucine-rich repeat kinase 1 in bone
por: Xing, Weirong R, et al.
Publicado: (2017)

Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide
por: Feng, Jianbo, et al.
Publicado: (2020)

Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy
por: Park, Sangwook, et al.
Publicado: (2016)

Leucine-rich repeat kinase 2 mutations and Parkinson’s disease: three questions
por: Greggio, Elisa, et al.
Publicado: (2009)

Structure and regulation of full-length human leucine-rich repeat kinase 1
por: Metcalfe, Riley D., et al.
Publicado: (2023)

Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
por: Lorin, Séverine, et al.
Publicado: (2013)

Identification and Characterization of a Leucine-Rich Repeat Kinase 2 (LRRK2) Consensus Phosphorylation Motif
por: Pungaliya, Pooja P., et al.
Publicado: (2010)

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor
por: Hanafusa, Hiroshi, et al.
Publicado: (2011)

Leucine-Rich Repeat Kinase 2-Linked Parkinson’s Disease: Clinical and Molecular Findings
por: Kumari, Udhaya, et al.
Publicado: (2010)

Ten Years and Counting: Moving Leucine-Rich Repeat Kinase 2 Inhibitors to the Clinic
por: West, Andrew B
Publicado: (2015)

Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma
por: Satoh, Shunpei, et al.
Publicado: (2016)

New Insights on Leucine-Rich Repeats Receptor-Like Kinase Orthologous Relationships in Angiosperms
por: Dufayard, Jean-François, et al.
Publicado: (2017)

The Double-Faceted Role of Leucine-Rich Repeat Kinase 2 in the Immunopathogenesis of Parkinson’s Disease
por: Zhang, Mengfei, et al.
Publicado: (2022)

Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival
por: Kang, Jongkyun, et al.
Publicado: (2023)

Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity
por: Sim, Joan Poh Ling, et al.
Publicado: (2019)

Origin and diversification of leucine-rich repeat receptor-like protein kinase (LRR-RLK) genes in plants
por: Liu, Ping-Li, et al.
Publicado: (2017)

Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines
por: Alharbi, Samah Abdulaali, et al.
Publicado: (2021)

Editorial: The Physiology and Pharmacology of Leucine-rich Repeat GPCRs
por: Arey, Brian J., et al.
Publicado: (2016)

Structure-Aware Annotation of Leucine-rich Repeat Domains
por: Xu, Boyan, et al.
Publicado: (2023)

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4
por: Russo, Isabella, et al.
Publicado: (2018)

Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity
por: Fernández, Belén, et al.
Publicado: (2022)

Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
por: Greggio, Elisa, et al.
Publicado: (2011)

Identical Twins with Leucine Rich Repeat Kinase Type 2 Mutations Discordant for Parkinson's Disease
por: Xiromerisiou, Georgia, et al.
Publicado: (2012)

Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson’s disease and beyond
por: Bae, Jae Ryul, et al.
Publicado: (2015)

Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia
por: Maekawa, Tatsunori, et al.
Publicado: (2016)

Map of physical interactions between extracellular domains of Arabidopsis leucine-rich repeat receptor kinases
por: Mott, G. Adam, et al.
Publicado: (2019)

Crystal structure of the leucine-rich repeat ectodomain of the plant immune receptor kinase SOBIR1
por: Hohmann, Ulrich, et al.
Publicado: (2019)

Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons
por: Maas, James W. Jr., et al.
Publicado: (2017)

Corrigendum: New Insights on Leucine-Rich Repeats Receptor-Like Kinase Orthologous Relationships in Angiosperms
por: Dufayard, Jean-François, et al.
Publicado: (2017)

The tale of proteolysis targeting chimeras (PROTACs) for Leucine‐Rich Repeat Kinase 2 (LRRK2)
por: Konstantinidou, Markella, et al.
Publicado: (2020)

A Genome-Wide Survey for Arabidopsis Leucine-Rich Repeat Receptor Kinases Implicated in Plant Immunity
por: Kemmerling, Birgit, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_12dj6h222kj67n6uc00v00svv7