Cargando…
Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease
BACKGROUND AND AIMS: We compared lung function parameters in nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD), and examined the association between lung function parameters and fibrosis severity in MAFLD. METHODS: In this cross-sectional study...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
XIA & HE Publishing Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039714/ https://www.ncbi.nlm.nih.gov/pubmed/35528974 http://dx.doi.org/10.14218/JCTH.2021.00306 |
_version_ | 1784694188790513664 |
---|---|
author | Miao, Lei Yang, Li Guo, Li-Sha Shi, Qiang-Qiang Zhou, Teng-Fei Chen, Yang Zhang, Huai Cai, Hui Xu, Zhi-Wei Yang, Shuan-Ying Lin, Hai Cheng, Zhe Zhu, Ming-Yang Nan, Xu Huang, Shuai Zheng, Ya-Wen Targher, Giovanni Byrne, Christopher D Li, Yu-Ping Zheng, Ming-Hua Chen, Cheng-Shui |
author_facet | Miao, Lei Yang, Li Guo, Li-Sha Shi, Qiang-Qiang Zhou, Teng-Fei Chen, Yang Zhang, Huai Cai, Hui Xu, Zhi-Wei Yang, Shuan-Ying Lin, Hai Cheng, Zhe Zhu, Ming-Yang Nan, Xu Huang, Shuai Zheng, Ya-Wen Targher, Giovanni Byrne, Christopher D Li, Yu-Ping Zheng, Ming-Hua Chen, Cheng-Shui |
author_sort | Miao, Lei |
collection | PubMed |
description | BACKGROUND AND AIMS: We compared lung function parameters in nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD), and examined the association between lung function parameters and fibrosis severity in MAFLD. METHODS: In this cross-sectional study, we randomly recruited 2,543 middle-aged individuals from 25 communities across four cities in China during 2016 and 2020. All participants received a health check-up including measurement of anthropometric parameters, biochemical variables, liver ultrasonography, and spirometry. The severity of liver disease was assessed by the fibrosis (FIB)-4 score. RESULTS: The prevalence of MAFLD was 20.4% (n=519) and that of NAFLD was 18.4% (n=469). After adjusting for age, sex, adiposity measures, smoking status, and significant alcohol intake, subjects with MAFLD had a significantly lower predicted forced vital capacity (FVC, 88.27±17.60% vs. 90.82±16.85%, p<0.05) and lower 1 s forced expiratory volume (FEV(1), 79.89±17.34 vs. 83.02±16.66%, p<0.05) than those with NAFLD. MAFLD with an increased FIB-4 score was significantly associated with decreased lung function. For each 1-point increase in FIB-4, FVC was diminished by 0.507 (95% CI: −0.840, −0.173, p=0.003), and FEV(1) was diminished by 0.439 (95% CI: −0.739, −0.140, p=0.004). The results remained unchanged when the statistical analyses was performed separately for men and women. CONCLUSIONS: MAFLD was significantly associated with a greater impairment of lung function parameters than NAFLD. |
format | Online Article Text |
id | pubmed-9039714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | XIA & HE Publishing Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90397142022-05-06 Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease Miao, Lei Yang, Li Guo, Li-Sha Shi, Qiang-Qiang Zhou, Teng-Fei Chen, Yang Zhang, Huai Cai, Hui Xu, Zhi-Wei Yang, Shuan-Ying Lin, Hai Cheng, Zhe Zhu, Ming-Yang Nan, Xu Huang, Shuai Zheng, Ya-Wen Targher, Giovanni Byrne, Christopher D Li, Yu-Ping Zheng, Ming-Hua Chen, Cheng-Shui J Clin Transl Hepatol Original Article BACKGROUND AND AIMS: We compared lung function parameters in nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD), and examined the association between lung function parameters and fibrosis severity in MAFLD. METHODS: In this cross-sectional study, we randomly recruited 2,543 middle-aged individuals from 25 communities across four cities in China during 2016 and 2020. All participants received a health check-up including measurement of anthropometric parameters, biochemical variables, liver ultrasonography, and spirometry. The severity of liver disease was assessed by the fibrosis (FIB)-4 score. RESULTS: The prevalence of MAFLD was 20.4% (n=519) and that of NAFLD was 18.4% (n=469). After adjusting for age, sex, adiposity measures, smoking status, and significant alcohol intake, subjects with MAFLD had a significantly lower predicted forced vital capacity (FVC, 88.27±17.60% vs. 90.82±16.85%, p<0.05) and lower 1 s forced expiratory volume (FEV(1), 79.89±17.34 vs. 83.02±16.66%, p<0.05) than those with NAFLD. MAFLD with an increased FIB-4 score was significantly associated with decreased lung function. For each 1-point increase in FIB-4, FVC was diminished by 0.507 (95% CI: −0.840, −0.173, p=0.003), and FEV(1) was diminished by 0.439 (95% CI: −0.739, −0.140, p=0.004). The results remained unchanged when the statistical analyses was performed separately for men and women. CONCLUSIONS: MAFLD was significantly associated with a greater impairment of lung function parameters than NAFLD. XIA & HE Publishing Inc. 2022-04-28 2022-01-04 /pmc/articles/PMC9039714/ /pubmed/35528974 http://dx.doi.org/10.14218/JCTH.2021.00306 Text en © 2022 Authors. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Miao, Lei Yang, Li Guo, Li-Sha Shi, Qiang-Qiang Zhou, Teng-Fei Chen, Yang Zhang, Huai Cai, Hui Xu, Zhi-Wei Yang, Shuan-Ying Lin, Hai Cheng, Zhe Zhu, Ming-Yang Nan, Xu Huang, Shuai Zheng, Ya-Wen Targher, Giovanni Byrne, Christopher D Li, Yu-Ping Zheng, Ming-Hua Chen, Cheng-Shui Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease |
title | Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease |
title_full | Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease |
title_fullStr | Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease |
title_full_unstemmed | Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease |
title_short | Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease |
title_sort | metabolic dysfunction-associated fatty liver disease is associated with greater impairment of lung function than nonalcoholic fatty liver disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039714/ https://www.ncbi.nlm.nih.gov/pubmed/35528974 http://dx.doi.org/10.14218/JCTH.2021.00306 |
work_keys_str_mv | AT miaolei metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT yangli metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT guolisha metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT shiqiangqiang metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT zhoutengfei metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT chenyang metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT zhanghuai metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT caihui metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT xuzhiwei metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT yangshuanying metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT linhai metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT chengzhe metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT zhumingyang metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT nanxu metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT huangshuai metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT zhengyawen metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT targhergiovanni metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT byrnechristopherd metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT liyuping metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT zhengminghua metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease AT chenchengshui metabolicdysfunctionassociatedfattyliverdiseaseisassociatedwithgreaterimpairmentoflungfunctionthannonalcoholicfattyliverdisease |