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Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications

Non-alcoholic fatty liver disease (NAFLD) is closely related to insulin resistance, type 2 diabetes mellitus and obesity. It is considered a multisystem disease and there is a strong association with cardiovascular disease and arterial hypertension, which interfere with changes in the coagulation sy...

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Autores principales: Ogresta, Doris, Mrzljak, Anna, Cigrovski Berkovic, Maja, Bilic-Curcic, Ines, Stojsavljevic-Shapeski, Sanja, Virovic-Jukic, Lucija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039716/
https://www.ncbi.nlm.nih.gov/pubmed/35528987
http://dx.doi.org/10.14218/JCTH.2021.00268
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author Ogresta, Doris
Mrzljak, Anna
Cigrovski Berkovic, Maja
Bilic-Curcic, Ines
Stojsavljevic-Shapeski, Sanja
Virovic-Jukic, Lucija
author_facet Ogresta, Doris
Mrzljak, Anna
Cigrovski Berkovic, Maja
Bilic-Curcic, Ines
Stojsavljevic-Shapeski, Sanja
Virovic-Jukic, Lucija
author_sort Ogresta, Doris
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is closely related to insulin resistance, type 2 diabetes mellitus and obesity. It is considered a multisystem disease and there is a strong association with cardiovascular disease and arterial hypertension, which interfere with changes in the coagulation system. Coagulation disorders are common in patients with hepatic impairment and are dependent on the degree of liver damage. Through a review of the literature, we consider and discuss possible disorders in the coagulation cascade and fibrinolysis, endothelial dysfunction and platelet abnormalities in patients with NAFLD.
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spelling pubmed-90397162022-05-06 Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications Ogresta, Doris Mrzljak, Anna Cigrovski Berkovic, Maja Bilic-Curcic, Ines Stojsavljevic-Shapeski, Sanja Virovic-Jukic, Lucija J Clin Transl Hepatol Review Article Non-alcoholic fatty liver disease (NAFLD) is closely related to insulin resistance, type 2 diabetes mellitus and obesity. It is considered a multisystem disease and there is a strong association with cardiovascular disease and arterial hypertension, which interfere with changes in the coagulation system. Coagulation disorders are common in patients with hepatic impairment and are dependent on the degree of liver damage. Through a review of the literature, we consider and discuss possible disorders in the coagulation cascade and fibrinolysis, endothelial dysfunction and platelet abnormalities in patients with NAFLD. XIA & HE Publishing Inc. 2022-04-28 2022-01-12 /pmc/articles/PMC9039716/ /pubmed/35528987 http://dx.doi.org/10.14218/JCTH.2021.00268 Text en © 2022 Authors. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ogresta, Doris
Mrzljak, Anna
Cigrovski Berkovic, Maja
Bilic-Curcic, Ines
Stojsavljevic-Shapeski, Sanja
Virovic-Jukic, Lucija
Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications
title Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications
title_full Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications
title_fullStr Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications
title_full_unstemmed Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications
title_short Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications
title_sort coagulation and endothelial dysfunction associated with nafld: current status and therapeutic implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039716/
https://www.ncbi.nlm.nih.gov/pubmed/35528987
http://dx.doi.org/10.14218/JCTH.2021.00268
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