Cargando…

Identifying novel SMYD3 interactors on the trail of cancer hallmarks

SMYD3 overexpression in several human cancers highlights its crucial role in carcinogenesis. Nonetheless, SMYD3 specific activity in cancer development and progression is currently under debate. Taking advantage of a library of rare tripeptides, which we first tested for their in vitro binding affin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fasano, Candida, Lepore Signorile, Martina, De Marco, Katia, Forte, Giovanna, Sanese, Paola, Grossi, Valentina, Simone, Cristiano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039736/ https://www.ncbi.nlm.nih.gov/pubmed/35495117 http://dx.doi.org/10.1016/j.csbj.2022.03.037

Ejemplares similares

The chromatin remodeling factors EP300 and TRRAP are novel SMYD3 interactors involved in the emerging ‘nonmutational epigenetic reprogramming’ cancer hallmark
por: Fasano, Candida, et al.
Publicado: (2023)

SMYD3 Modulates the HGF/MET Signaling Pathway in Gastric Cancer
por: De Marco, Katia, et al.
Publicado: (2023)

SMYD3 Modulates AMPK-mTOR Signaling Balance in Cancer Cell Response to DNA Damage
por: Lepore Signorile, Martina, et al.
Publicado: (2023)

APC Splicing Mutations Leading to In-Frame Exon 12 or Exon 13 Skipping Are Rare Events in FAP Pathogenesis and Define the Clinical Outcome
por: Disciglio, Vittoria, et al.
Publicado: (2021)

Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape
por: Grossi, Valentina, et al.
Publicado: (2019)

Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models
por: Lepore Signorile, Martina, et al.
Publicado: (2023)

Playing on the Dark Side: SMYD3 Acts as a Cancer Genome Keeper in Gastrointestinal Malignancies
por: Sanese, Paola, et al.
Publicado: (2021)

Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality
por: Sanese, Paola, et al.
Publicado: (2020)

Identification and Somatic Characterization of the Germline PTEN Promoter Variant rs34149102 in a Family with Gastrointestinal and Breast Tumors
por: Disciglio, Vittoria, et al.
Publicado: (2022)

c-MYC Protein Stability Is Sustained by MAPKs in Colorectal Cancer
por: Lepore Signorile, Martina, et al.
Publicado: (2022)

Gastric polyposis and desmoid tumours as a new familial adenomatous polyposis clinical variant associated with APC mutation at the extreme 3′-end
por: Disciglio, Vittoria, et al.
Publicado: (2020)

Colorectal Cancer Chemoprevention: A Dream Coming True?
por: Lepore Signorile, Martina, et al.
Publicado: (2023)

Tumor Testing and Genetic Analysis to Identify Lynch Syndrome Patients in an Italian Colorectal Cancer Cohort
por: Pantaleo, Antonino, et al.
Publicado: (2023)

Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes
por: Forte, Giovanna, et al.
Publicado: (2022)

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer
por: Grossi, Valentina, et al.
Publicado: (2018)

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase
por: Talibov, Vladimir O., et al.
Publicado: (2021)

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy
por: Celestini, Valentina, et al.
Publicado: (2018)

Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids
por: Lepore Signorile, Martina, et al.
Publicado: (2021)

Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis
por: Fasano, Candida, et al.
Publicado: (2022)

FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular Stress Response
por: Fasano, Candida, et al.
Publicado: (2019)

FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs
por: Sanese, Paola, et al.
Publicado: (2019)

Histone and DNA Methylation as Epigenetic Regulators of DNA Damage Repair in Gastric Cancer and Emerging Therapeutic Opportunities
por: De Marco, Katia, et al.
Publicado: (2023)

CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype
por: Mancarella, Serena, et al.
Publicado: (2022)

Correction: CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype
por: Mancarella, Serena, et al.
Publicado: (2023)

Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma
por: Lucarelli, Giuseppe, et al.
Publicado: (2018)

SMYD3: An Oncogenic Driver Targeting Epigenetic Regulation and Signaling Pathways
por: Bottino, Cinzia, et al.
Publicado: (2020)

From Genetics to Histomolecular Characterization: An Insight into Colorectal Carcinogenesis in Lynch Syndrome
por: Lepore Signorile, Martina, et al.
Publicado: (2021)

Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species
por: Calpena, Eduardo, et al.
Publicado: (2015)

SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1
por: Yoshioka, Yuichiro, et al.
Publicado: (2016)

Upregulation of SMYD3 and SMYD3 VNTR 3/3 polymorphism increase the risk of hepatocellular carcinoma
por: Binh, Mai Thanh, et al.
Publicado: (2020)

Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia
por: Cai, Lei, et al.
Publicado: (2018)

The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development
por: Fittipaldi, Raffaella, et al.
Publicado: (2021)

Regulation of cytohesins by their interactors in the nervous system
por: Zhai, Yuqi, et al.
Publicado: (2023)

Characterization of the rs2802292 SNP identifies FOXO3A as a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes
por: Forte, Giovanna, et al.
Publicado: (2014)

SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells
por: Toghill, Bradley J., et al.
Publicado: (2018)

An RNAi-Based Suppressor Screen Identifies Interactors of the Myt1 Ortholog of Caenorhabditis elegans
por: Allen, Anna K., et al.
Publicado: (2014)

Hallmarks of cancer and hallmarks of aging
por: Blagosklonny, Mikhail V.
Publicado: (2022)

An Overview of the Ferroptosis Hallmarks in Friedreich’s Ataxia
por: Turchi, Riccardo, et al.
Publicado: (2020)

SMYD1, an SRF-Interacting Partner, Is Involved in Angiogenesis
por: Ye, Xiangli, et al.
Publicado: (2016)

SMYD proteins in immunity: dawning of a new era
por: Doughan, Maysaa, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_t42lc9bq9hn54hn850785db9mv