Homozygous ALS-linked FUS P525L mutations cell- autonomously perturb transcriptome profile and chemoreceptor signaling in human iPSC microglia

Amyotrophic lateral sclerosis is a fatal disease pathologically typified by motor and cortical neurodegeneration as well as microgliosis. The FUS P525L mutation is highly penetrant and causes ALS cases with earlier disease onset and more aggressive progression. To date, how P525L mutations may affec...

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Detalles Bibliográficos
Autores principales: Kerk, Sze Yen, Bai, Yu, Smith, Janell, Lalgudi, Pranav, Hunt, Charleen, Kuno, Junko, Nuara, John, Yang, Tao, Lanza, Kathryn, Chan, Newton, Coppola, Angel, Tang, Qian, Espert, Jennifer, Jones, Henderson, Fannell, Casey, Zambrowicz, Brian, Chiao, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039753/
https://www.ncbi.nlm.nih.gov/pubmed/35120624
http://dx.doi.org/10.1016/j.stemcr.2022.01.004

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