Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration

Cell-based therapies face challenges, including poor cell survival, immune rejection, and integration into pathologic tissue. We conducted an open-label phase 1/2a clinical trial to assess the safety and preliminary efficacy of a subretinal implant consisting of a polarized monolayer of allogeneic h...

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Detalles Bibliográficos
Autores principales: Kashani, Amir H., Lebkowski, Jane S., Hinton, David R., Zhu, Danhong, Faynus, Mohamed A., Chen, Sanford, Rahhal, Firas M., Avery, Robert L., Salehi-Had, Hani, Chan, Clement, Palejwala, Neal, Ingram, April, Dang, Wei, Lin, Chih-Min, Mitra, Debbie, Martinez-Camarillo, Juan Carlos, Bailey, Jeff, Arnold, Cassidy, Pennington, Britney O., Rao, Narsing, Johnson, Lincoln V., Clegg, Dennis O., Humayun, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039755/
https://www.ncbi.nlm.nih.gov/pubmed/35120620
http://dx.doi.org/10.1016/j.stemcr.2022.01.001

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