Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells

Rett syndrome may be treated by reactivating the silent copy of Mecp2 from the inactive X chromosome in female cells. Most studies that model Mecp2 reactivation have used mouse fibroblasts rather than neural cells, which would be critical for phenotypic reversal, and rely on fluorescent reporters th...

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Detalles Bibliográficos
Autores principales: Mira-Bontenbal, H., Tan, B., Gontan, C., Goossens, S., Boers, R.G., Boers, J.B., Dupont, C., van Royen, M.E., IJcken, W.F.J., French, P., Bedalov, A., Gribnau, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039756/
https://www.ncbi.nlm.nih.gov/pubmed/35148843
http://dx.doi.org/10.1016/j.stemcr.2022.01.008

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