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Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesis

Bone morphogenetic protein (BMP) cascades are upregulated during bone marrow-derived stromal cell (BMSC) chondrogenesis, contributing to hypertrophy and preventing effective BMSC-mediated cartilage repair. Previous work demonstrated that a proprietary BMP inhibitor prevented BMSC hypertrophy, yieldi...

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Detalles Bibliográficos
Autores principales:	Franco, Rose Ann G., McKenna, Eamonn, Robey, Pamela G., Shajib, Md. Shaffiulah, Crawford, Ross W., Doran, Michael R., Futrega, Kathryn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039850/ https://www.ncbi.nlm.nih.gov/pubmed/35180395 http://dx.doi.org/10.1016/j.stemcr.2022.01.016

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