Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers

In vitro expansion of human primordial germ cell-like cells (hPGCLCs), a pluripotent stem cell-derived PGC model, has proved challenging due to rapid loss of primordial germ cell (PGC)-like identity and limited cell survival/proliferation. Here, we describe long-term culture hPGCLCs (LTC-hPGCLCs), w...

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Detalles Bibliográficos
Autores principales: Kobayashi, Mutsumi, Kobayashi, Misato, Odajima, Junko, Shioda, Keiko, Hwang, Young Sun, Sasaki, Kotaro, Chatterjee, Pranam, Kramme, Christian, Kohman, Richie E., Church, George M., Loehr, Amanda R., Weiss, Robert S., Jüppner, Harald, Gell, Joanna J., Lau, Ching C., Shioda, Toshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039862/
https://www.ncbi.nlm.nih.gov/pubmed/35148847
http://dx.doi.org/10.1016/j.stemcr.2022.01.012

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