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Incidence, Risk Factors and Outcomes of Kidney and Liver Cyst Infection in Kidney Transplant Recipient With ADPKD

INTRODUCTION: Cyst infection is a known complication of autosomal dominant polycystic kidney disease (ADPKD). Here, we describe incidence, risk factors, clinical presentation, and outcomes of cyst infection in kidney transplant recipient. METHODS: We conducted a single-center retrospective cohort st...

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Autores principales: Ronsin, Charles, Chaba, Anis, Suchanek, Ondrej, Coindre, Jean-Philippe, Kerleau, Clarisse, Garandeau, Claire, Houzet, Aurélie, Cantarovich, Diego, Dantal, Jacques, Blancho, Gilles, Giral, Magali, Couvrat-Desvergnes, Grégoire, Ville, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039903/
https://www.ncbi.nlm.nih.gov/pubmed/35497795
http://dx.doi.org/10.1016/j.ekir.2022.01.1062
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author Ronsin, Charles
Chaba, Anis
Suchanek, Ondrej
Coindre, Jean-Philippe
Kerleau, Clarisse
Garandeau, Claire
Houzet, Aurélie
Cantarovich, Diego
Dantal, Jacques
Blancho, Gilles
Giral, Magali
Couvrat-Desvergnes, Grégoire
Ville, Simon
author_facet Ronsin, Charles
Chaba, Anis
Suchanek, Ondrej
Coindre, Jean-Philippe
Kerleau, Clarisse
Garandeau, Claire
Houzet, Aurélie
Cantarovich, Diego
Dantal, Jacques
Blancho, Gilles
Giral, Magali
Couvrat-Desvergnes, Grégoire
Ville, Simon
author_sort Ronsin, Charles
collection PubMed
description INTRODUCTION: Cyst infection is a known complication of autosomal dominant polycystic kidney disease (ADPKD). Here, we describe incidence, risk factors, clinical presentation, and outcomes of cyst infection in kidney transplant recipient. METHODS: We conducted a single-center retrospective cohort study of patients with ADPKD with renal allografts between January 1, 2009, and October 31, 2020. Cyst infection diagnosis was based on previously described clinical and radiological criteria, using positron emission tomography when available. RESULTS: A total of 296 patients with ADPKD with renal allografts were included, and 21 patients experienced 22 episodes of cyst infection over a median follow-up of 4 (2–7) years. The cumulative incidence rate was 3% at 1 year, 6 % at 5 years, and 12% at 10 years after transplantation. In multivariate analysis, history of cyst infection before transplantation was the only significant risk factor identified to predict the occurrence of cyst infection after kidney transplantation (hazard ratio [HR] 3.47, 95% CI 1.29–9.31). The clinical presentation at diagnosis of cyst infection included isolated fever in 5 (23%) episodes, acute kidney injury in 12 (55%), and severe sepsis/septic shock in 3 (14%) episodes. Among the 16 (73%) episodes with culture positivity, Escherichia coli was the most common pathogen. There was no difference between early (≤1 year after transplantation) and late (>1 year) cyst infection episodes in terms of clinical presentation and outcomes. Cyst infection was significantly associated with graft loss (HR 3.93, 95% CI 1.21–12.80), but no causal relationship could be established. CONCLUSION: Incidence of cyst infection in ADPKD after kidney transplantation is low, history of cyst infection representing the main risk factor.
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spelling pubmed-90399032022-04-27 Incidence, Risk Factors and Outcomes of Kidney and Liver Cyst Infection in Kidney Transplant Recipient With ADPKD Ronsin, Charles Chaba, Anis Suchanek, Ondrej Coindre, Jean-Philippe Kerleau, Clarisse Garandeau, Claire Houzet, Aurélie Cantarovich, Diego Dantal, Jacques Blancho, Gilles Giral, Magali Couvrat-Desvergnes, Grégoire Ville, Simon Kidney Int Rep Clinical Research INTRODUCTION: Cyst infection is a known complication of autosomal dominant polycystic kidney disease (ADPKD). Here, we describe incidence, risk factors, clinical presentation, and outcomes of cyst infection in kidney transplant recipient. METHODS: We conducted a single-center retrospective cohort study of patients with ADPKD with renal allografts between January 1, 2009, and October 31, 2020. Cyst infection diagnosis was based on previously described clinical and radiological criteria, using positron emission tomography when available. RESULTS: A total of 296 patients with ADPKD with renal allografts were included, and 21 patients experienced 22 episodes of cyst infection over a median follow-up of 4 (2–7) years. The cumulative incidence rate was 3% at 1 year, 6 % at 5 years, and 12% at 10 years after transplantation. In multivariate analysis, history of cyst infection before transplantation was the only significant risk factor identified to predict the occurrence of cyst infection after kidney transplantation (hazard ratio [HR] 3.47, 95% CI 1.29–9.31). The clinical presentation at diagnosis of cyst infection included isolated fever in 5 (23%) episodes, acute kidney injury in 12 (55%), and severe sepsis/septic shock in 3 (14%) episodes. Among the 16 (73%) episodes with culture positivity, Escherichia coli was the most common pathogen. There was no difference between early (≤1 year after transplantation) and late (>1 year) cyst infection episodes in terms of clinical presentation and outcomes. Cyst infection was significantly associated with graft loss (HR 3.93, 95% CI 1.21–12.80), but no causal relationship could be established. CONCLUSION: Incidence of cyst infection in ADPKD after kidney transplantation is low, history of cyst infection representing the main risk factor. Elsevier 2022-02-03 /pmc/articles/PMC9039903/ /pubmed/35497795 http://dx.doi.org/10.1016/j.ekir.2022.01.1062 Text en © 2022 International Society of Nephrology. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Clinical Research
Ronsin, Charles
Chaba, Anis
Suchanek, Ondrej
Coindre, Jean-Philippe
Kerleau, Clarisse
Garandeau, Claire
Houzet, Aurélie
Cantarovich, Diego
Dantal, Jacques
Blancho, Gilles
Giral, Magali
Couvrat-Desvergnes, Grégoire
Ville, Simon
Incidence, Risk Factors and Outcomes of Kidney and Liver Cyst Infection in Kidney Transplant Recipient With ADPKD
title Incidence, Risk Factors and Outcomes of Kidney and Liver Cyst Infection in Kidney Transplant Recipient With ADPKD
title_full Incidence, Risk Factors and Outcomes of Kidney and Liver Cyst Infection in Kidney Transplant Recipient With ADPKD
title_fullStr Incidence, Risk Factors and Outcomes of Kidney and Liver Cyst Infection in Kidney Transplant Recipient With ADPKD
title_full_unstemmed Incidence, Risk Factors and Outcomes of Kidney and Liver Cyst Infection in Kidney Transplant Recipient With ADPKD
title_short Incidence, Risk Factors and Outcomes of Kidney and Liver Cyst Infection in Kidney Transplant Recipient With ADPKD
title_sort incidence, risk factors and outcomes of kidney and liver cyst infection in kidney transplant recipient with adpkd
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039903/
https://www.ncbi.nlm.nih.gov/pubmed/35497795
http://dx.doi.org/10.1016/j.ekir.2022.01.1062
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