Study on hypoglycemic effects of irradiated ginseng adventitious roots

We aimed to explore the effects of the (60)Co-γ irradiated ginseng adventitious root (GAR) with different radiation doses on the hypoglycemic effects of its extract (GARSE) through in vivo and in vitro experiments. The total saponin of GARSE was increased by 4.50% after 5 kGy irradiation, and the 2,...

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Detalles Bibliográficos
Autores principales: Zhang, Lu, Qi, Xin, Lu, Xin-tong, Cui, Cheng-bi, Gao, Xue-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article(s) from the Special Issue on Advances on dietary polysaccharides and oligosaccharides: structure and bioactivity by Dr. Hussain and Dr. You
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039912/
https://www.ncbi.nlm.nih.gov/pubmed/35499036
http://dx.doi.org/10.1016/j.fochx.2022.100234
Descripción
Sumario:We aimed to explore the effects of the (60)Co-γ irradiated ginseng adventitious root (GAR) with different radiation doses on the hypoglycemic effects of its extract (GARSE) through in vivo and in vitro experiments. The total saponin of GARSE was increased by 4.50% after 5 kGy irradiation, and the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability was enhanced by 5.10%. At 50 μg/mL, GARSE irradiated by 5 kGy displayed superior protective effects on human glomerular mesangial cells (HMCs) with high glucose damage. After feeding type 1 diabetes mellitus (T1DM) mice with GARSE irradiated by 5 kGy at 500 mg/kg·BW for 4 weeks, the glucose values was decreased by 16.0% compared with the unirradiated. The Keap1/Nrf2/HO-1 pathway was activated and the oxidative stress was attenuated, which further alleviated T1DM.

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