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Bioactive peptides produced by engineered probiotics and other food-grade bacteria: A review
Synthetic biology is employed for the study and design of engineered microbes with new and improved therapeutic functions. The main advantage of synthetic biology is the selective genetic manipulation of living organisms with desirable beneficial effects such as probiotics. Engineering technologies...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039921/ https://www.ncbi.nlm.nih.gov/pubmed/35498967 http://dx.doi.org/10.1016/j.fochx.2021.100196 |
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author | Romero-Luna, Haydee Eliza Hernández-Mendoza, Adrián González-Córdova, Aarón Fernando Peredo-Lovillo, Audry |
author_facet | Romero-Luna, Haydee Eliza Hernández-Mendoza, Adrián González-Córdova, Aarón Fernando Peredo-Lovillo, Audry |
author_sort | Romero-Luna, Haydee Eliza |
collection | PubMed |
description | Synthetic biology is employed for the study and design of engineered microbes with new and improved therapeutic functions. The main advantage of synthetic biology is the selective genetic manipulation of living organisms with desirable beneficial effects such as probiotics. Engineering technologies have contributed to the edition of metabolic processes involved in the mechanisms of action of probiotics, such as the generation of bioactive peptides. Hence, current information related to bioactive peptides, produced by different engineering probiotics, with antimicrobial, antiviral, antidiabetic, and antihypertensive activities, as well as their potential use as functional ingredients, is discussed here. Besides, the effectiveness and safety aspects of these bioactive peptides were also described. |
format | Online Article Text |
id | pubmed-9039921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-90399212022-04-27 Bioactive peptides produced by engineered probiotics and other food-grade bacteria: A review Romero-Luna, Haydee Eliza Hernández-Mendoza, Adrián González-Córdova, Aarón Fernando Peredo-Lovillo, Audry Food Chem X Article(s) from the Special Issue on Novel proteins and peptides for human consumption: sources, chemistry and function by Dr. González-Córdova and Dr. Sáyago-Ayerdi Synthetic biology is employed for the study and design of engineered microbes with new and improved therapeutic functions. The main advantage of synthetic biology is the selective genetic manipulation of living organisms with desirable beneficial effects such as probiotics. Engineering technologies have contributed to the edition of metabolic processes involved in the mechanisms of action of probiotics, such as the generation of bioactive peptides. Hence, current information related to bioactive peptides, produced by different engineering probiotics, with antimicrobial, antiviral, antidiabetic, and antihypertensive activities, as well as their potential use as functional ingredients, is discussed here. Besides, the effectiveness and safety aspects of these bioactive peptides were also described. Elsevier 2021-12-22 /pmc/articles/PMC9039921/ /pubmed/35498967 http://dx.doi.org/10.1016/j.fochx.2021.100196 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article(s) from the Special Issue on Novel proteins and peptides for human consumption: sources, chemistry and function by Dr. González-Córdova and Dr. Sáyago-Ayerdi Romero-Luna, Haydee Eliza Hernández-Mendoza, Adrián González-Córdova, Aarón Fernando Peredo-Lovillo, Audry Bioactive peptides produced by engineered probiotics and other food-grade bacteria: A review |
title | Bioactive peptides produced by engineered probiotics and other food-grade bacteria: A review |
title_full | Bioactive peptides produced by engineered probiotics and other food-grade bacteria: A review |
title_fullStr | Bioactive peptides produced by engineered probiotics and other food-grade bacteria: A review |
title_full_unstemmed | Bioactive peptides produced by engineered probiotics and other food-grade bacteria: A review |
title_short | Bioactive peptides produced by engineered probiotics and other food-grade bacteria: A review |
title_sort | bioactive peptides produced by engineered probiotics and other food-grade bacteria: a review |
topic | Article(s) from the Special Issue on Novel proteins and peptides for human consumption: sources, chemistry and function by Dr. González-Córdova and Dr. Sáyago-Ayerdi |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039921/ https://www.ncbi.nlm.nih.gov/pubmed/35498967 http://dx.doi.org/10.1016/j.fochx.2021.100196 |
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