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Neurokinin receptors and their implications in various autoimmune diseases

Neurokinin receptors belong to the GPCRs family and are ubiquitously expressed throughout the nervous and immune systems. Neurokinin receptors in coordination with neurokinins playing an important role in many physiological processes, including smooth muscle contraction, secretion, proliferation, an...

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Detalles Bibliográficos
Autores principales: Mishra, Amrita, Lal, Girdhari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040085/
https://www.ncbi.nlm.nih.gov/pubmed/35492389
http://dx.doi.org/10.1016/j.crimmu.2021.06.001
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author Mishra, Amrita
Lal, Girdhari
author_facet Mishra, Amrita
Lal, Girdhari
author_sort Mishra, Amrita
collection PubMed
description Neurokinin receptors belong to the GPCRs family and are ubiquitously expressed throughout the nervous and immune systems. Neurokinin receptors in coordination with neurokinins playing an important role in many physiological processes, including smooth muscle contraction, secretion, proliferation, and nociception. They also contribute to various disease conditions such as inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, psoriasis, and cancer. Neurokinin receptors antagonist are potent and highly selective and showing success in treating chemotherapy-induced nausea and vomiting. In this review, discuss the various neurokinin receptor expression on immune cells and their importance in various inflammatory and autoimmune diseases and their therapeutic importance.
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spelling pubmed-90400852022-04-27 Neurokinin receptors and their implications in various autoimmune diseases Mishra, Amrita Lal, Girdhari Curr Res Immunol Review Article Neurokinin receptors belong to the GPCRs family and are ubiquitously expressed throughout the nervous and immune systems. Neurokinin receptors in coordination with neurokinins playing an important role in many physiological processes, including smooth muscle contraction, secretion, proliferation, and nociception. They also contribute to various disease conditions such as inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, psoriasis, and cancer. Neurokinin receptors antagonist are potent and highly selective and showing success in treating chemotherapy-induced nausea and vomiting. In this review, discuss the various neurokinin receptor expression on immune cells and their importance in various inflammatory and autoimmune diseases and their therapeutic importance. Elsevier 2021-07-01 /pmc/articles/PMC9040085/ /pubmed/35492389 http://dx.doi.org/10.1016/j.crimmu.2021.06.001 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Mishra, Amrita
Lal, Girdhari
Neurokinin receptors and their implications in various autoimmune diseases
title Neurokinin receptors and their implications in various autoimmune diseases
title_full Neurokinin receptors and their implications in various autoimmune diseases
title_fullStr Neurokinin receptors and their implications in various autoimmune diseases
title_full_unstemmed Neurokinin receptors and their implications in various autoimmune diseases
title_short Neurokinin receptors and their implications in various autoimmune diseases
title_sort neurokinin receptors and their implications in various autoimmune diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040085/
https://www.ncbi.nlm.nih.gov/pubmed/35492389
http://dx.doi.org/10.1016/j.crimmu.2021.06.001
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