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Neurokinin receptors and their implications in various autoimmune diseases
Neurokinin receptors belong to the GPCRs family and are ubiquitously expressed throughout the nervous and immune systems. Neurokinin receptors in coordination with neurokinins playing an important role in many physiological processes, including smooth muscle contraction, secretion, proliferation, an...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040085/ https://www.ncbi.nlm.nih.gov/pubmed/35492389 http://dx.doi.org/10.1016/j.crimmu.2021.06.001 |
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author | Mishra, Amrita Lal, Girdhari |
author_facet | Mishra, Amrita Lal, Girdhari |
author_sort | Mishra, Amrita |
collection | PubMed |
description | Neurokinin receptors belong to the GPCRs family and are ubiquitously expressed throughout the nervous and immune systems. Neurokinin receptors in coordination with neurokinins playing an important role in many physiological processes, including smooth muscle contraction, secretion, proliferation, and nociception. They also contribute to various disease conditions such as inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, psoriasis, and cancer. Neurokinin receptors antagonist are potent and highly selective and showing success in treating chemotherapy-induced nausea and vomiting. In this review, discuss the various neurokinin receptor expression on immune cells and their importance in various inflammatory and autoimmune diseases and their therapeutic importance. |
format | Online Article Text |
id | pubmed-9040085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-90400852022-04-27 Neurokinin receptors and their implications in various autoimmune diseases Mishra, Amrita Lal, Girdhari Curr Res Immunol Review Article Neurokinin receptors belong to the GPCRs family and are ubiquitously expressed throughout the nervous and immune systems. Neurokinin receptors in coordination with neurokinins playing an important role in many physiological processes, including smooth muscle contraction, secretion, proliferation, and nociception. They also contribute to various disease conditions such as inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, psoriasis, and cancer. Neurokinin receptors antagonist are potent and highly selective and showing success in treating chemotherapy-induced nausea and vomiting. In this review, discuss the various neurokinin receptor expression on immune cells and their importance in various inflammatory and autoimmune diseases and their therapeutic importance. Elsevier 2021-07-01 /pmc/articles/PMC9040085/ /pubmed/35492389 http://dx.doi.org/10.1016/j.crimmu.2021.06.001 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Mishra, Amrita Lal, Girdhari Neurokinin receptors and their implications in various autoimmune diseases |
title | Neurokinin receptors and their implications in various autoimmune diseases |
title_full | Neurokinin receptors and their implications in various autoimmune diseases |
title_fullStr | Neurokinin receptors and their implications in various autoimmune diseases |
title_full_unstemmed | Neurokinin receptors and their implications in various autoimmune diseases |
title_short | Neurokinin receptors and their implications in various autoimmune diseases |
title_sort | neurokinin receptors and their implications in various autoimmune diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040085/ https://www.ncbi.nlm.nih.gov/pubmed/35492389 http://dx.doi.org/10.1016/j.crimmu.2021.06.001 |
work_keys_str_mv | AT mishraamrita neurokininreceptorsandtheirimplicationsinvariousautoimmunediseases AT lalgirdhari neurokininreceptorsandtheirimplicationsinvariousautoimmunediseases |