Loss of thymic function promotes EAE relapse in anti-CD52-treated mice

Anti-CD52 treatment creates a long-lasting CD4 T cell lymphopenia and reduces multiple sclerosis (MS) relapses in humans. In contrast, anti-CD52 therapy at disease onset more fully suppresses experimental autoimmune encephalomyelitis (EAE) in mice, and T cell repopulation is rapid. To test whether p...

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Detalles Bibliográficos
Autores principales: Adegoke, Adeolu O., Lin, Jiaxin, Anderson, Colin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040091/
https://www.ncbi.nlm.nih.gov/pubmed/35496821
http://dx.doi.org/10.1016/j.crimmu.2022.03.001

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