FGF21 regulates alcohol intake: New hopes on the rise for alcohol use disorder treatment?

FGF21 is a liver-derived hormone primarily involved in glucose/lipid metabolism. A recent study by Flippo and colleagues(1) demonstrates that administration of FGF21 or an FGF21 analog suppresses alcohol consumption in rodents and non-human primates, likely through an amygdalo-striatal circuit.

Detalles Bibliográficos
Autores principales: Wang, Tammy, Farokhnia, Mehdi, Leggio, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040172/
https://www.ncbi.nlm.nih.gov/pubmed/35492877
http://dx.doi.org/10.1016/j.xcrm.2022.100578
Descripción
Sumario:FGF21 is a liver-derived hormone primarily involved in glucose/lipid metabolism. A recent study by Flippo and colleagues(1) demonstrates that administration of FGF21 or an FGF21 analog suppresses alcohol consumption in rodents and non-human primates, likely through an amygdalo-striatal circuit.

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