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The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell
For most vaccination studies, the assessment of vaccine-induced CD4(+) and CD8(+) T cells has relied upon the measurement of antigen-specific polyfunctional cells, typically using recombinant antigen or peptide pools. However, this approach leaves open the question as to whether or not these cells a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040373/ https://www.ncbi.nlm.nih.gov/pubmed/35493495 http://dx.doi.org/10.3389/fimmu.2022.869057 |
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author | Lewinsohn, David Michael Lewinsohn, Deborah Anne |
author_facet | Lewinsohn, David Michael Lewinsohn, Deborah Anne |
author_sort | Lewinsohn, David Michael |
collection | PubMed |
description | For most vaccination studies, the assessment of vaccine-induced CD4(+) and CD8(+) T cells has relied upon the measurement of antigen-specific polyfunctional cells, typically using recombinant antigen or peptide pools. However, this approach leaves open the question as to whether or not these cells are responsive to the Mtb-infected cell within the context of Mtb infection and hence leaves open the possibility that a key parameter of vaccine immunogenicity may be overlooked. In this review, we discuss the case that these measurements almost certainly over-estimate the capacity of both CD4(+) and CD8(+) T cells to recognize the Mtb-infected cell. |
format | Online Article Text |
id | pubmed-9040373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90403732022-04-27 The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell Lewinsohn, David Michael Lewinsohn, Deborah Anne Front Immunol Immunology For most vaccination studies, the assessment of vaccine-induced CD4(+) and CD8(+) T cells has relied upon the measurement of antigen-specific polyfunctional cells, typically using recombinant antigen or peptide pools. However, this approach leaves open the question as to whether or not these cells are responsive to the Mtb-infected cell within the context of Mtb infection and hence leaves open the possibility that a key parameter of vaccine immunogenicity may be overlooked. In this review, we discuss the case that these measurements almost certainly over-estimate the capacity of both CD4(+) and CD8(+) T cells to recognize the Mtb-infected cell. Frontiers Media S.A. 2022-04-12 /pmc/articles/PMC9040373/ /pubmed/35493495 http://dx.doi.org/10.3389/fimmu.2022.869057 Text en Copyright © 2022 Lewinsohn and Lewinsohn https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lewinsohn, David Michael Lewinsohn, Deborah Anne The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell |
title | The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell |
title_full | The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell |
title_fullStr | The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell |
title_full_unstemmed | The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell |
title_short | The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell |
title_sort | missing link in correlates of protective tuberculosis immunity: recognizing the infected cell |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040373/ https://www.ncbi.nlm.nih.gov/pubmed/35493495 http://dx.doi.org/10.3389/fimmu.2022.869057 |
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