COVID-19 vaccines provide better protection against related pneumonia than previous symptomatic infection

OBJECTIVES: To compare, in a real-world scenario, the protective effect of vaccination and previous laboratory-confirmed symptomatic infection on the risk of COVID-19 pneumonia. METHODS: A retrospective study was conducted and 46,998 adults with laboratory-confirmed COVID-19 were enrolled. Risk rati...

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Detalles Bibliográficos
Autores principales: Murillo-Zamora, Efrén, Trujillo, Xóchitl, Huerta, Miguel, Ríos-Silva, Mónica, Guzmán-Esquivel, José, Benites-Godínez, Verónica, Ochoa-Castro, María Regina, Guzmán-Solórzano, José Alejandro, Mendoza-Cano, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040470/
https://www.ncbi.nlm.nih.gov/pubmed/35477053
http://dx.doi.org/10.1016/j.ijid.2022.04.047
Descripción
Sumario:OBJECTIVES: To compare, in a real-world scenario, the protective effect of vaccination and previous laboratory-confirmed symptomatic infection on the risk of COVID-19 pneumonia. METHODS: A retrospective study was conducted and 46,998 adults with laboratory-confirmed COVID-19 were enrolled. Risk ratios (RRs) and 95% confidence intervals (CIs) were used to evaluate the effect of the evaluated exposures on the risk of pneumonia. RESULTS: In multiple analysis and after adjusting by reinfection status, vaccinated participants were at reduced risk of developing pneumonia (RR = 0.974, 95% CI 0.965–0.983). The association of having had a previous infection was not significant (RR = 1.001, 95% CI 0.969–1.034). CONCLUSION: Our results suggest, and if later replicated, that COVID-19 vaccines provide better protection against pneumonia than previous symptomatic infections. Therefore, offering vaccination to all eligible subjects despite past COVID-19 infections might be relevant to reducing the pandemic-related burden.

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