Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2

Lipid nanoparticle (LNP)-mRNA vaccines offer protection against COVID-19; however, multiple variant lineages caused widespread breakthrough infections. Here, we generate LNP-mRNAs specifically encoding wild-type (WT), B.1.351, and B.1.617 SARS-CoV-2 spikes, and systematically study their immune resp...

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Detalles Bibliográficos
Autores principales: Peng, Lei, Renauer, Paul A., Ökten, Arya, Fang, Zhenhao, Park, Jonathan J., Zhou, Xiaoyu, Lin, Qianqian, Dong, Matthew B., Filler, Renata, Xiong, Qiancheng, Clark, Paul, Lin, Chenxiang, Wilen, Craig B., Chen, Sidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040489/
https://www.ncbi.nlm.nih.gov/pubmed/35561673
http://dx.doi.org/10.1016/j.xcrm.2022.100634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040489/
https://www.ncbi.nlm.nih.gov/pubmed/35561673
http://dx.doi.org/10.1016/j.xcrm.2022.100634

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