Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives

A visible-light-driven cascade radical cyclization process of N-methacryloyl-2-phenylbenzimidazole has been established with α-carbonyl alkyl bromide. This protocol provides an efficient and practical method for the synthesis of various α-carbonyl alkyl-substituted benzimidazo[2,1-α]isoquinolin-6(5H...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Jing, Huang, Hong-Li, Wang, Chen, Li, Yinghua, Li, Huaqiang, Hu, Honggang, He, Shipeng, Tang, Hua, Gao, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040576/
https://www.ncbi.nlm.nih.gov/pubmed/35479569
http://dx.doi.org/10.1039/d1ra05936j
_version_ 1784694364847472640
author Liu, Jing
Huang, Hong-Li
Wang, Chen
Li, Yinghua
Li, Huaqiang
Hu, Honggang
He, Shipeng
Tang, Hua
Gao, Fei
author_facet Liu, Jing
Huang, Hong-Li
Wang, Chen
Li, Yinghua
Li, Huaqiang
Hu, Honggang
He, Shipeng
Tang, Hua
Gao, Fei
author_sort Liu, Jing
collection PubMed
description A visible-light-driven cascade radical cyclization process of N-methacryloyl-2-phenylbenzimidazole has been established with α-carbonyl alkyl bromide. This protocol provides an efficient and practical method for the synthesis of various α-carbonyl alkyl-substituted benzimidazo[2,1-α]isoquinolin-6(5H)-ones in outstanding yields, mild reaction conditions and excellent functional group tolerance.
format Online
Article
Text
id pubmed-9040576
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90405762022-04-26 Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives Liu, Jing Huang, Hong-Li Wang, Chen Li, Yinghua Li, Huaqiang Hu, Honggang He, Shipeng Tang, Hua Gao, Fei RSC Adv Chemistry A visible-light-driven cascade radical cyclization process of N-methacryloyl-2-phenylbenzimidazole has been established with α-carbonyl alkyl bromide. This protocol provides an efficient and practical method for the synthesis of various α-carbonyl alkyl-substituted benzimidazo[2,1-α]isoquinolin-6(5H)-ones in outstanding yields, mild reaction conditions and excellent functional group tolerance. The Royal Society of Chemistry 2021-09-01 /pmc/articles/PMC9040576/ /pubmed/35479569 http://dx.doi.org/10.1039/d1ra05936j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Liu, Jing
Huang, Hong-Li
Wang, Chen
Li, Yinghua
Li, Huaqiang
Hu, Honggang
He, Shipeng
Tang, Hua
Gao, Fei
Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives
title Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives
title_full Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives
title_fullStr Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives
title_full_unstemmed Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives
title_short Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives
title_sort visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5h)-one derivatives
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040576/
https://www.ncbi.nlm.nih.gov/pubmed/35479569
http://dx.doi.org/10.1039/d1ra05936j
work_keys_str_mv AT liujing visiblelightdrivencascaderadicalcyclizationtowardthesynthesisofacarbonylalkylsubstitutedbenzimidazo21aisoquinolin65honederivatives
AT huanghongli visiblelightdrivencascaderadicalcyclizationtowardthesynthesisofacarbonylalkylsubstitutedbenzimidazo21aisoquinolin65honederivatives
AT wangchen visiblelightdrivencascaderadicalcyclizationtowardthesynthesisofacarbonylalkylsubstitutedbenzimidazo21aisoquinolin65honederivatives
AT liyinghua visiblelightdrivencascaderadicalcyclizationtowardthesynthesisofacarbonylalkylsubstitutedbenzimidazo21aisoquinolin65honederivatives
AT lihuaqiang visiblelightdrivencascaderadicalcyclizationtowardthesynthesisofacarbonylalkylsubstitutedbenzimidazo21aisoquinolin65honederivatives
AT huhonggang visiblelightdrivencascaderadicalcyclizationtowardthesynthesisofacarbonylalkylsubstitutedbenzimidazo21aisoquinolin65honederivatives
AT heshipeng visiblelightdrivencascaderadicalcyclizationtowardthesynthesisofacarbonylalkylsubstitutedbenzimidazo21aisoquinolin65honederivatives
AT tanghua visiblelightdrivencascaderadicalcyclizationtowardthesynthesisofacarbonylalkylsubstitutedbenzimidazo21aisoquinolin65honederivatives
AT gaofei visiblelightdrivencascaderadicalcyclizationtowardthesynthesisofacarbonylalkylsubstitutedbenzimidazo21aisoquinolin65honederivatives

Ejemplares similares