Deletion of Orc4 during oogenesis severely reduces polar body extrusion and blocks zygotic DNA replication

Origin recognition complex subunit 4 (ORC4) is a DNA-binding protein required for DNA replication. During oocyte maturation, after the last oocyte DNA replication step and before zygotic DNA replication, the oocyte undergoes two meiotic cell divisions in which half the DNA is ejected in much smaller...

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Detalles Bibliográficos
Autores principales: Nguyen, Hieu, Wu, Hongwen, Ung, Anna, Yamazaki, Yukiko, Fogelgren, Ben, Ward, W Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9040667/
https://www.ncbi.nlm.nih.gov/pubmed/34977916
http://dx.doi.org/10.1093/biolre/ioab237

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