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Causes of mortality in elderly UICC stage III colon cancer (CC) patients––Tumor‐related death and competing risks from the German AIO colorectal study group Colopredict Plus (CPP) registry

BACKGROUND: Colon cancer (CC) is a disease of elderly patients (pts.) with a median age of 73 years (yrs.). Lack of data about the effects of adjuvant chemotherapy (ACT) is caused by underrepresentation of this clinically relevant cohort in interventional trials. We analyzed real‐world data from the...

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Autores principales: Nöpel‐Dünnebacke, Stefanie, Jütte, Hendrick, Denz, Robin, Feder, Inke Sabine, Kraeft, Anna‐Lena, Lugnier, Celine, Teschendorf, Christian, Collette, Daniela, Böhner, Hinrich, Engel, Lars, Mueller, Lothar, Hartmann, Frank, Kaiser, Ulrich, Bruch, Harald‐Robert, Hollerbach, Stephan, Arnold, Dirk, Timmesfeld, Nina, Tannapfel, Andrea, Reinacher‐Schick, Anke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041084/
https://www.ncbi.nlm.nih.gov/pubmed/35146948
http://dx.doi.org/10.1002/cam4.4540
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author Nöpel‐Dünnebacke, Stefanie
Jütte, Hendrick
Denz, Robin
Feder, Inke Sabine
Kraeft, Anna‐Lena
Lugnier, Celine
Teschendorf, Christian
Collette, Daniela
Böhner, Hinrich
Engel, Lars
Mueller, Lothar
Hartmann, Frank
Kaiser, Ulrich
Bruch, Harald‐Robert
Hollerbach, Stephan
Arnold, Dirk
Timmesfeld, Nina
Tannapfel, Andrea
Reinacher‐Schick, Anke
author_facet Nöpel‐Dünnebacke, Stefanie
Jütte, Hendrick
Denz, Robin
Feder, Inke Sabine
Kraeft, Anna‐Lena
Lugnier, Celine
Teschendorf, Christian
Collette, Daniela
Böhner, Hinrich
Engel, Lars
Mueller, Lothar
Hartmann, Frank
Kaiser, Ulrich
Bruch, Harald‐Robert
Hollerbach, Stephan
Arnold, Dirk
Timmesfeld, Nina
Tannapfel, Andrea
Reinacher‐Schick, Anke
author_sort Nöpel‐Dünnebacke, Stefanie
collection PubMed
description BACKGROUND: Colon cancer (CC) is a disease of elderly patients (pts.) with a median age of 73 years (yrs.). Lack of data about the effects of adjuvant chemotherapy (ACT) is caused by underrepresentation of this clinically relevant cohort in interventional trials. We analyzed real‐world data from the German CPP registry with regard to a possible benefit of ACT in elderly (70+ yrs.) versus younger pts. (50 to <70 yrs.) taking cause‐specific deaths into account. METHODS: We analyzed the effect of age and ACT on overall survival (OS) and cause‐specific death of stage III pts. using Cox regression. RESULTS: In total, 1558 pts. were analyzed and follow‐up was 24.6 months. 62.6% of the elderly received ACT whereas 91.1% of younger pts. (p < 0.001). Oxaliplatin combinations were significantly less often given to older than younger pts. (38.8% vs. 88.9%; p < 0.001). Mean Charlson comorbidity score was significantly lower in pts. that received ACT (0.61) than in those without ACT (1.16; p < 0.001). ACT was an independent positive prognostic factor for cancer‐related death in elderly pts. even in pts. 75+ yrs. No significant difference in the effect of ACT could be observed between age groups (interaction: cancer‐specific death HR = 1.7948, p = 0.1079; death of other cause HR = 0.7384, p = 0.6705). CONCLUSION: ACT was an independent positive prognostic factor for OS. There may be a cohort of elderly with less co‐morbidities who benefit from ACT.
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spelling pubmed-90410842022-04-28 Causes of mortality in elderly UICC stage III colon cancer (CC) patients––Tumor‐related death and competing risks from the German AIO colorectal study group Colopredict Plus (CPP) registry Nöpel‐Dünnebacke, Stefanie Jütte, Hendrick Denz, Robin Feder, Inke Sabine Kraeft, Anna‐Lena Lugnier, Celine Teschendorf, Christian Collette, Daniela Böhner, Hinrich Engel, Lars Mueller, Lothar Hartmann, Frank Kaiser, Ulrich Bruch, Harald‐Robert Hollerbach, Stephan Arnold, Dirk Timmesfeld, Nina Tannapfel, Andrea Reinacher‐Schick, Anke Cancer Med Clinical Cancer Research BACKGROUND: Colon cancer (CC) is a disease of elderly patients (pts.) with a median age of 73 years (yrs.). Lack of data about the effects of adjuvant chemotherapy (ACT) is caused by underrepresentation of this clinically relevant cohort in interventional trials. We analyzed real‐world data from the German CPP registry with regard to a possible benefit of ACT in elderly (70+ yrs.) versus younger pts. (50 to <70 yrs.) taking cause‐specific deaths into account. METHODS: We analyzed the effect of age and ACT on overall survival (OS) and cause‐specific death of stage III pts. using Cox regression. RESULTS: In total, 1558 pts. were analyzed and follow‐up was 24.6 months. 62.6% of the elderly received ACT whereas 91.1% of younger pts. (p < 0.001). Oxaliplatin combinations were significantly less often given to older than younger pts. (38.8% vs. 88.9%; p < 0.001). Mean Charlson comorbidity score was significantly lower in pts. that received ACT (0.61) than in those without ACT (1.16; p < 0.001). ACT was an independent positive prognostic factor for cancer‐related death in elderly pts. even in pts. 75+ yrs. No significant difference in the effect of ACT could be observed between age groups (interaction: cancer‐specific death HR = 1.7948, p = 0.1079; death of other cause HR = 0.7384, p = 0.6705). CONCLUSION: ACT was an independent positive prognostic factor for OS. There may be a cohort of elderly with less co‐morbidities who benefit from ACT. John Wiley and Sons Inc. 2022-02-11 /pmc/articles/PMC9041084/ /pubmed/35146948 http://dx.doi.org/10.1002/cam4.4540 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Nöpel‐Dünnebacke, Stefanie
Jütte, Hendrick
Denz, Robin
Feder, Inke Sabine
Kraeft, Anna‐Lena
Lugnier, Celine
Teschendorf, Christian
Collette, Daniela
Böhner, Hinrich
Engel, Lars
Mueller, Lothar
Hartmann, Frank
Kaiser, Ulrich
Bruch, Harald‐Robert
Hollerbach, Stephan
Arnold, Dirk
Timmesfeld, Nina
Tannapfel, Andrea
Reinacher‐Schick, Anke
Causes of mortality in elderly UICC stage III colon cancer (CC) patients––Tumor‐related death and competing risks from the German AIO colorectal study group Colopredict Plus (CPP) registry
title Causes of mortality in elderly UICC stage III colon cancer (CC) patients––Tumor‐related death and competing risks from the German AIO colorectal study group Colopredict Plus (CPP) registry
title_full Causes of mortality in elderly UICC stage III colon cancer (CC) patients––Tumor‐related death and competing risks from the German AIO colorectal study group Colopredict Plus (CPP) registry
title_fullStr Causes of mortality in elderly UICC stage III colon cancer (CC) patients––Tumor‐related death and competing risks from the German AIO colorectal study group Colopredict Plus (CPP) registry
title_full_unstemmed Causes of mortality in elderly UICC stage III colon cancer (CC) patients––Tumor‐related death and competing risks from the German AIO colorectal study group Colopredict Plus (CPP) registry
title_short Causes of mortality in elderly UICC stage III colon cancer (CC) patients––Tumor‐related death and competing risks from the German AIO colorectal study group Colopredict Plus (CPP) registry
title_sort causes of mortality in elderly uicc stage iii colon cancer (cc) patients––tumor‐related death and competing risks from the german aio colorectal study group colopredict plus (cpp) registry
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041084/
https://www.ncbi.nlm.nih.gov/pubmed/35146948
http://dx.doi.org/10.1002/cam4.4540
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