Discovery of 8-prenylnaringenin from hop (Humulus lupulus L.) as a potent monoacylglycerol lipase inhibitor for treatments of neuroinflammation and Alzheimer's disease

Monoacylglycerol lipase (MAGL), a serine hydrolase, converts endocannabinoid 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA) and glycerol in the brain and plays a bidirectional role in controlling nueroinflammation. MAGL, involved in Alzheimer's and Parkinson's diseases, is a promis...

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Detalles Bibliográficos
Autores principales: Tung, Min-Che, Fung, Kit-Man, Hsu, Hsin-Mie, Tseng, Tien-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041313/
https://www.ncbi.nlm.nih.gov/pubmed/35498911
http://dx.doi.org/10.1039/d1ra05311f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041313/
https://www.ncbi.nlm.nih.gov/pubmed/35498911
http://dx.doi.org/10.1039/d1ra05311f

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